Редактирование: PPARD (раздел)

==Publications==

{{medline-entry
|title=[[PPARD]]  294C overrepresentation in general and long-lived population in China Bama longevity area and unique relationships between [[PPARD]]  294T/C polymorphism and serum lipid profiles.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25873088
|abstract=The  294T/C polymorphism in the peroxisome proliferator-activated receptor delta ([[PPARD]]) gene is associated with hyperlipidemia in several younger populations, but results are still inconsistence across ethnic groups and its possible impact on the lipid profiles of long-lived individuals remains unexploited. Here, we aimed to evaluate the possible correlation between [[PPARD]]  294T/C and serum lipid levels in a long-lived population in Bama, a region known for longevity situated in Guangxi, China. Genotyping of [[PPARD]]  294T/C polymorphism was conducted in 505 long-lived inhabitants (aged 90 and above, long-lived group, LG) and 468 healthy controls (aged 60-75, non-long-lived group, non-LG) recruited from Bama area. No difference in allelic and genotypic frequencies was found between the two groups (P>0.05). However, C-allele and C-genotype (TC and CC) were significantly more frequent in the females of non-LG than were LG after sex stratification. CC carriers exhibited higher LDL-C level in LG (P<0.05) but lower TC, [[TG]] and LDL-C in non-LG (P<0.05 for each) than TT carriers; C allele carriers (TC/CC) in LG exhibited higher TC, [[TG]], and LDL-C levels as compared with the same genotype and the same lipid parameter in non-LG (P<0.05 for each). LDL-C in LG was correlated with genotypes while TC, [[TG]], and LDL-C in non-LG were correlated with genotypes (P<0.05-0.001). Our results suggest that there were different impact patterns of [[PPARD]]  294T/C polymorphism on lipid profiles between long-lived cohort and average population in Bama area and this may be one of the genetic bases of its longevity.
|mesh-terms=* Aged
* Aged, 80 and over
* Asian Continental Ancestry Group
* Case-Control Studies
* China
* Cholesterol
* Cholesterol, HDL
* Cholesterol, LDL
* Female
* Genetic Association Studies
* Humans
* Lipids
* Longevity
* Male
* Middle Aged
* PPAR delta
* Polymorphism, Single Nucleotide
* Triglycerides

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356147
}}
{{medline-entry
|title=[Genotype and allele frequencies of UCP and PPAR gene families in residents of besieged Leningrad and in the control group].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25826986
|abstract=Genotype and allele frequencies of uncoupling proteins 2 and 3 genes ([[UCP2]] and [[UCP3]]) and peroxisome proliferator-activated receptors genes ([[PPARA]], [[PPARD]] and [[PPARG]]) were studied in 206 residents of the siege and in 139 individuals of more than 69 years old (control group). Studied polymorphisms included [[UCP2]] (Ala55Val), [[UCP3]] (C-55T), [[PPARA]] (G/C), [[PPARD]] ( 294T/C), and [[PPARG]] (Pro12Ala). The G allele and the G/G genotype ([[PPARA]]) were overrepresented in the group of survivors and C/C ([[UCP3]]) genotype prevailed in the women of besieged Leningrad compared to relevant control groups of the persons of the same age who did not suffered hungry disaster. Feasible protective effects of [[PPARA]] gene allele G and C allele of [[UCP2]] genes are briefly discussed.
|mesh-terms=* Aged
* Aged, 80 and over
* Case-Control Studies
* Cities
* Data Interpretation, Statistical
* Female
* Gene Frequency
* Genotype
* Humans
* Ion Channels
* Longevity
* Male
* Malnutrition
* Mitochondrial Proteins
* PPAR alpha
* PPAR delta
* PPAR gamma
* Polymorphism, Single Nucleotide
* Russia
* Survivors
* Uncoupling Protein 2
* Uncoupling Protein 3
* World War II


}}