Редактирование: NOX5 (раздел)

==Publications==

{{medline-entry
|title=Expression of mRNA for ROS-generating NADPH oxidases in the aging stomach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15820617
|abstract=Oxidative damage is thought to play a key role in the aging of various organ systems. In this study, we have therefore analyzed mRNA expression of ROS-generating NADPH oxidases in the aging stomach. Gastric biopsies of hospitalized geriatric patients were analyzed for histology (Sidney classification), and real-time PCR was used to quantify mRNA expression of the superoxide-generating NADPH oxidases [[NOX1]], NOX2, and [[NOX5]]. We found that stomach biopsies of elderly patients expressed [[NOX5]] and NOX2 mRNA, but not [[NOX1]]. The mRNA expression of [[NOX5]] (a lymphocyte NADPH oxidase) neither depended on age nor on the results of the stomach histology. In contrast, mRNA expression of NOX2 (phagocyte NADPH oxidase) was a function of two variables. Increased NOX2 mRNA levels were observed in biopsies with signs of chronic inflammation (p=0.01). Interestingly, however, there was also an age-dependent increase in NOX2 mRNA levels (p=0.01). We conclude that in elderly patients the gastric mRNA expression of the ROS-generating enzyme NOX2 increases as a function of age, possibly contributing to stomach aging and gastric vulnerability of the elderly.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Biopsy
* Chronic Disease
* Female
* Gastritis
* Gene Expression
* Humans
* Male
* Membrane Glycoproteins
* Membrane Proteins
* NADPH Oxidase 1
* NADPH Oxidase 2
* NADPH Oxidase 5
* NADPH Oxidases
* Polymerase Chain Reaction
* RNA, Messenger
* Reactive Oxygen Species
* Severity of Illness Index
* Stomach

|full-text-url=https://sci-hub.do/10.1016/j.exger.2005.01.007
}}