Редактирование: NOTCH3 (раздел)

==Publications==

{{medline-entry
|title=Whole-Exome Sequencing of an Exceptional Longevity Cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29750252
|abstract=Centenarians represent a unique cohort to study the genetic basis for longevity and factors determining the risk of neurodegenerative disorders, including Alzheimer's disease (AD). The estimated genetic contribution to longevity is highest in centenarians and super-cententenarians, but few genetic variants have been shown to clearly impact this phenotype. While the genetic risk for AD and other dementias is now well understood, the frequency of known dementia risk variants in centenarians is not fully characterized. To address these questions, we performed whole-exome sequencing on 100 individuals of 98-108 years age in search of genes with large effect sizes towards the exceptional aging phenotype. Overall, we were unable to identify a rare protein-altering variant or individual genes with an increased burden of rare variants associated with exceptional longevity. Gene burden analysis revealed three genes of nominal statistical significance associated with extreme aging, including [[LYST]], [[MDN1]], and [[RBMXL1]]. Several genes with variants conferring an increased risk for AD and other dementias were identified, including [[TREM2]], [[EPHA1]], [[ABCA7]], [[PLD3]], [[MAPT]], and [[NOTCH3]]. Larger centenarian studies will be required to further elucidate the genetic basis for longevity, and factors conferring protection against age-dependent neurodegenerative syndromes.
|mesh-terms=* Age Factors
* Aged, 80 and over
* Alzheimer Disease
* Cohort Studies
* Dementia
* Female
* Humans
* Longevity
* Male
* Risk Factors
* Whole Exome Sequencing
|keywords=* Alzheimer’s disease
* Centenarian
* Dementia
* SKAT
* Whole-exome sequencing
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6696723
}}
{{medline-entry
|title=Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of [[CSF1R]] and [[NOTCH3]].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29544907
|abstract=Mendelian adult-onset leukodystrophies are a spectrum of rare inherited progressive neurodegenerative disorders affecting the white matter of the central nervous system. Among these, cerebral autosomal dominant and recessive arteriopathy with subcortical infarcts and leukoencephalopathy, cerebroretinal vasculopathy, metachromatic leukodystrophy, hereditary diffuse leukoencephalopathy with spheroids, and vanishing white matter disease present with rapidly progressive dementia as dominant feature and are caused by mutations in [[NOTCH3]], [[HTRA1]], [[TREX1]], [[ARSA]], [[CSF1R]], [[EIF2B1]], [[EIF2B2]], [[EIF2B3]], [[EIF2B4]], and [[EIF2B5]], respectively. Given the rare incidence of these disorders and the lack of unequivocally diagnostic features, leukodystrophies are frequently misdiagnosed with common sporadic dementing diseases such as Alzheimer's disease (AD), raising the question of whether these overlapping phenotypes may be explained by shared genetic risk factors. To investigate this intriguing hypothesis, we have combined gene expression analysis (1) in 6 different AD mouse strains (APPPS1, HOTASTPM, HETASTPM, TPM, TAS10, and TAU) at 5 different developmental stages (embryo [E15], 2, 4, 8, and 18 months), (2) in APPPS1 primary cortical neurons under stress conditions (oxygen-glucose deprivation) and single-variant-based and single-gene-based (c-alpha test and sequence kernel association test (SKAT)) genetic screening in a cohort composed of 332 Caucasian late-onset AD patients and 676 Caucasian elderly controls. Csf1r was significantly overexpressed (log2FC > 1, adj. p-value < 0.05) in the cortex and hippocampus of aged HOTASTPM mice with extensive Aβ dense-core plaque pathology. We identified 3 likely pathogenic mutations in [[CSF1R]] TK domain (p.L868R, p.Q691H, and p.H703Y) in our discovery and validation cohort, composed of 465 AD and mild cognitive impairment (MCI) Caucasian patients from the United Kingdom. Moreover, [[NOTCH3]] was a significant hit in the c-alpha test (adj p-value = 0.01). Adult-onset Mendelian leukodystrophy genes are not common factors implicated in AD. Nevertheless, our study suggests a potential pathogenic link between [[NOTCH3]], [[CSF1R]], and sporadic late-onset AD, which warrants further investigation.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Alzheimer Disease
* Animals
* Cerebral Cortex
* Cohort Studies
* European Continental Ancestry Group
* Female
* Genetic Association Studies
* Hippocampus
* Humans
* Leukodystrophy, Metachromatic
* Male
* Mice
* Middle Aged
* Mutation
* Receptor, Notch3
* Receptors, Granulocyte-Macrophage Colony-Stimulating Factor
* Risk Factors
|keywords=* Alzheimer's disease
* CSF1R
* Mendelian leukodystrophies
* NOTCH3
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5937905
}}
{{medline-entry
|title=Length of paternal lifespan is manifested in the DNA methylome of their nonagenarian progeny.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26436701
|abstract=The heritability of lifespan is 20-30%, but only a few genes associated with longevity have been identified. To explain this discrepancy, the inheritance of epigenetic features, such as DNA methylation, have been proposed to contribute to the heritability of lifespan.We investigated whether parental lifespan is associated with DNA methylation profile in nonagenarians. A regression model, adjusted for differences in blood cell proportions, identified 659 CpG sites where the level of methylation was associated with paternal lifespan. However, no association was observed between maternal lifespan and DNA methylation. The 659 CpG sites associated with paternal lifespan were enriched outside of CpG islands and were located in genes associated with development and morphogenesis, as well as cell signaling. The largest difference in the level of methylation between the progeny of the shortest-lived and longest-lived fathers was identified for CpG sites mapping to [[CXXC5]]. In addition, the level of methylation in three Notch-genes (NOTCH1, [[NOTCH3]] and NOTCH4) was also associated with paternal lifespan.There are implications for the inheritance of acquired traits via epigenetic mechanisms in mammals. Here we describe DNA methylation features that are associated with paternal lifespan, and we speculate that the identified CpG sites may represent intergenerational epigenetic inheritance. 
|mesh-terms=* Aged, 80 and over
* Aging
* CpG Islands
* DNA
* DNA Methylation
* Epigenesis, Genetic
* Fathers
* Female
* Genetic Association Studies
* Humans
* Longevity
* Male
* Prospective Studies
* Proto-Oncogene Proteins
* Quantitative Trait, Heritable
* Receptor, Notch1
* Receptor, Notch3
* Receptor, Notch4
* Receptors, Notch
* Siblings
|keywords=* DNA methylation
* Gerotarget
* intergenerational inheritance
* lifespan
* longevity
* methylome
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4741551
}}