Редактирование: NDUFV1 (раздел)

==Publications==

{{medline-entry
|title=Contribution of genetic polymorphisms on functional status at very old age: a gene-based analysis of 38 genes (311 SNPs) in the oxidative stress pathway.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24462499
|abstract=Preservation of functional ability is a well-recognized marker of longevity. At a molecular level, a major determinant of the physiological decline occurring with aging is the imbalance between production and accumulation of oxidative damage to macromolecules, together with a decreased efficiency of stress response to avoid or repair such damage. In this paper we investigated the association of 38 genes (311 SNPs) belonging to the pro-antioxidant pathways with physical and cognitive performances, by analyzing single SNP and gene-based associations with Hand Grip strength (HG), Activities of Daily Living (ADL), Walking Speed (WS), Mini Mental State Examination (MMSE) and Composite Cognitive Score (CCS) in a Cohort of 1089 Danish nonagenarians. Moreover, for each gene analyzed in the pro-antioxidant pathway, we tested the influence on longitudinal survival. In the whole sample, nominal associations were found for [[TXNRD1]] variability with ADL and WS, [[NDUFS1]] and [[UCP3]] with HG and WS, [[GCLC]] and [[UCP2]] with WS (p<0.05). Stronger associations although not holding the multiple comparison correction, were observed between MMSE and [[NDUFV1]], [[MT1A]] and [[GSTP1]] variability (p<0.009). Moreover, we found that association between genetic variability in the pro-antioxidant pathway and functional status at old age is influenced by sex. In particular, most significant associations were observed in nonagenarian females, between HG scores and [[GLRX]] and [[UCP3]] variability, between ADL levels and [[TXNRD1]], MMSE and [[MT1A]] genetic variability. In males, a borderline statistically significant association with ADL level was found for [[UQCRFS1]] gene. Nominally significant associations in relation to survival were found in the female sample only with [[SOD2]], [[NDUFS1]], [[UCP3]] and [[TXNRD1]] variability, the latter two confirming previous observations reported in the same cohort. Overall, our work supports the evidence that genes belonging to the pro-anti-oxidant pathway are able to modulate physical and cognitive performance after the ninth decade of life, finally influencing extreme survival. 
|mesh-terms=* Activities of Daily Living
* Aged
* Aged, 80 and over
* Cognition
* Female
* Humans
* Male
* Oxidative Stress
* Polymorphism, Single Nucleotide
|keywords=* 1905 Danish Cohort
* Aging
* Functional status
* Oxidative stress
* Survival at old age
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050201
}}