Редактирование: MVK (раздел)

==Publications==

{{medline-entry
|title=Impact of maternal aging on the molecular signature of human cumulus cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22968048
|abstract=To investigate the impact of maternal aging on the molecular signature of cumulus cells. Experimental study. Research laboratory. Patients, young fertile oocyte donors (n = 40) and infertile women of advanced maternal age (40-45 years; n = 48), donated, with Institutional Review Board consent, cumulus cells during routine infertility treatment. None. Proteomic and gene expression profiles of cumulus cells. Proteomic analysis identified a total of 1,423 cumulus cell proteins. Statistical analysis revealed 110 (7.7%) proteins to be differentially expressed in relation to female aging (>1.5-fold change). Pathway annotation revealed significant involvement in metabolism (ACAT2, [[HSD17B4]], [[ALDH9A1]], [[MVK]], [[CYP11A1]], and FDFT1), oxidative phosphorylation (OP; [[NDUFA1]], [[UQCRC1]], MT-ATP6, ATP5I, and MT-ATP8), and post-transcriptional mechanisms (KHSRP, [[SFPQ]], [[DDX46]], [[SNRPF]], [[ADAR]], NHPL1, and U2AF2) relative to advanced maternal age. Gene expression analysis also revealed altered profiles in cumulus cells from women in their early to mid-40s. This novel study reveals that the cumulus cell molecular signature, at both the gene and protein level, is impacted by advanced maternal aging. A compromised follicular environment is evident with altered energy metabolism and post-transcriptional processes.
|mesh-terms=* Adult
* Aging
* Cells, Cultured
* Cumulus Cells
* Female
* Humans
* Maternal Age
* Middle Aged
* Oocyte Donation
* Proteome

|full-text-url=https://sci-hub.do/10.1016/j.fertnstert.2012.08.012
}}