Редактирование: MUC6 (раздел)

==Publications==

{{medline-entry
|title=[Lacrimal gland-associated mucins. Age related production and their role in the pathophysiology of dry eye].
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/15678360
|abstract=The secretory cells of the human lacrimal gland show a PAS-positive reaction in cytochemical staining procedures, suggesting the production of mucous substances. Recently, these substances were differentiated according to modern molecular classifications. Expression studies detected mRNA for [[MUC1]], [[MUC4]], [[MUC5AC]], [[MUC5B]], [[MUC6]], and [[MUC7]], whereas [[MUC2]] transcripts were absent in all samples investigated. Immunohistochemistry revealed membrane-bound [[MUC1]] at the apical surface of acinar cells, [[MUC5AC]] associated with goblet cells of excretory ducts, [[MUC5B]] and [[MUC7]] in the cytoplasm of acinar cells, and [[MUC7]] also in epithelial cells of excretory ducts. [[MUC2]] (RT-PCR negative) and [[MUC6]] (RT-PCR positive) were not detectable by immunohistochemistry. [[MUC4]] mRNA was present in all samples from patients treated for dry eye but only in 6 of 30 glands from individuals who did not receive treatment with artificial tears. Dot-blot analyses clearly revealed increased amounts of [[MUC4]], [[MUC5AC]] and [[MUC5B]] in the glands of elderly women who received treatment for dry eye as compared to the remaining samples. These results confirm that the human lacrimal gland synthesizes a spectrum of mucins, some of which might be involved in the pathophysiology of dry eye syndrome.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Child
* Dry Eye Syndromes
* Female
* Humans
* Lacrimal Apparatus
* Male
* Middle Aged
* Mucins
* Tissue Distribution

|full-text-url=https://sci-hub.do/10.1007/s00347-004-1075-4
}}
{{medline-entry
|title=Metaplasia of the duodenum shows a Helicobacter pylori-correlated differentiation into gastric-type protein expression.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12612884
|abstract=The origin of gastric metaplasia of the duodenum (GMD) remains enigmatic. We studied expression of mucins and trefoil peptides in GMD to gain insight into its phenotype and origin. We examined duodenal tissue of 95 patients (0 to 83 years old, 26 with gastric Helicobacter pylori infection) for the presence of GMD. Expression was examined immunohistochemically of secretory mucins ([[MUC2]], [[MUC5AC]], [[MUC5B]], and [[MUC6]]), trefoil peptides ([[TFF1]], [[TFF2]], and [[TFF3]]), and sucrase-isomaltase ([[SI]]). GMD, found in 37 patients, correlated positively to gastric H. pylori infection, age, and villus atrophy. [[MUC2]] and [[TFF3]], expressed in normal goblet cells, were absent from 100% and 87% of GMD, respectively. GMD ubiquitously expressed [[MUC5AC]], whereas [[MUC5AC]] expression in adjacent goblet cells was closely correlated with the extent of GMD. [[TFF1]], [[TFF2]], and [[MUC6]] were found in 84%, 92%, and 65% of GMD, respectively. [[MUC5B]] was absent from epithelium and GMD. [[SI]], expressed by villus enterocytes, was absent from GMD. Brunner's glands ubiquitously expressed [[MUC5B]], [[MUC6]], and [[TFF2]]. GMD was characterized by the expression of gastric-type proteins [[MUC5AC]], [[MUC6]], [[TFF1]], and [[TFF2]] and the absence of intestinal markers [[MUC2]], [[TFF3]], and [[SI]]. In terms of the location of metaplastic cells, our results suggest that epithelial cells migrating toward villus tips switch to gastric-type secretory cells. Positive correlation with infection suggests an inductive role H. pylori in the development of GMD.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Brunner Glands
* Cell Differentiation
* Child
* Child, Preschool
* Duodenum
* Gastric Mucosa
* Goblet Cells
* Growth Substances
* Helicobacter Infections
* Helicobacter pylori
* Humans
* Infant
* Metaplasia
* Middle Aged
* Mucin 5AC
* Mucin-2
* Mucin-5B
* Mucin-6
* Mucins
* Muscle Proteins
* Neuropeptides
* Peptides
* Proteins
* Stomach Diseases
* Trefoil Factor-1
* Trefoil Factor-2
* Trefoil Factor-3
* Tumor Suppressor Proteins

|full-text-url=https://sci-hub.do/10.1053/hupa.2003.15
}}
{{medline-entry
|title=Brunner's glands: a structural, histochemical and pathological profile.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/11148980
|abstract=Brunner's glands are unique to mammalian species and in eutherians are confined primarily to the submucosa of the proximal duodenum. In the majority of species examined, they begin at the gastrointestinal junction and extend for variable distances distally in the wall of the proximal small intestine. Ducts of individual glands empty either directly into the intestinal lumen or unite with overlying intestinal glands (crypts of Lieberkühn) dependent on the species. Secretory units of Brunner's glands consist of epithelial tubules that show frequent distal branchings. The secretory units, with the exception of those found in rabbits and horses, consist primarily of a mucin producing cell type. However, other cell types normally associated with the overlying intestinal epithelium may be encountered scattered within the secretory units reflecting the developmental origin of these glands. Secretion from Brunner's glands contributes to a layer of mucus that forms a slippery, viscoelastic gel that lubricates the mucosal lining of the proximal intestinal tract. The unique capacity of this mucus layer to protect delicate underlying epithelial surfaces is due primarily to the gel-forming properties of its glycoprotein molecules. Mucin glycoproteins produced by Brunner's glands consist primarily but not exclusively of O-linked oligosaccharides attached to the central protein core of the glycoprotein molecule. Human Brunner's glands produce class III mucin glycoproteins and are thought to be the product of mucin gene [[MUC6]] which is assigned to chromosome 11 (11p15-11p15.5 chromosome region). In addition to mucin glycoproteins and a limited amount of bicarbonate, numerous additional factors (epidermal growth factor, trefoil peptides, bactericidal factors, proteinase inhibitors, and surface-active lipids) have been identified within the secretory product of Brunner's glands. These factors, incorporated into the mucus layer, guard against the degradation of this protective barrier and underlying mucosa by gastric acid, pancreatic enzymes, and other surface active agents associated with this region. Yet other factors produced by Brunner's glands function to provide active and passive immunological defense mechanisms, promote cellular proliferation and differentiation, as well as contribute factors that elevate the pH of luminal contents of this region by promoting secretion of the intestinal mucosa, pancreatic secretion and gall bladder contraction. Additional insights concerning the role of Brunner's glands in the mammalian gastrointestinal tract as well as their possible evolution in this class of vertebrates have been gained from a basic understanding of their pathobiology.
|mesh-terms=* Adaptation, Physiological
* Aging
* Animals
* Brunner Glands
* Duodenum
* Enteroendocrine Cells
* Humans
* Intestinal Mucosa
* Microscopy, Electron
* Mucins
* Neovascularization, Physiologic
* Staining and Labeling


}}