Редактирование: MR1 (раздел)

==Publications==

{{medline-entry
|title=Human blood MAIT cell subsets defined using [[MR1]] tetramers.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29437263
|abstract=Mucosal-associated invariant T (MAIT) cells represent up to 10% of circulating human T cells. They are usually defined using combinations of non-lineage-specific (surrogate) markers such as anti-[[TRAV1-2]], CD161, IL-18Rα and CD26. The development of [[MR1]]-Ag tetramers now permits the specific identification of MAIT cells based on T-cell receptor specificity. Here, we compare these approaches for identifying MAIT cells and show that surrogate markers are not always accurate in identifying these cells, particularly the [[CD4]]  fraction. Moreover, while all MAIT cell subsets produced comparable levels of IFNγ, [[TNF]] and IL-17A, the [[CD4]]  population produced more IL-2 than the other subsets. In a human ontogeny study, we show that the frequencies of most [[MR1]] tetramer  MAIT cells, with the exception of [[CD4]]  MAIT cells, increased from birth to about 25 years of age and declined thereafter. We also demonstrate a positive association between the frequency of MAIT cells and other unconventional T cells including Natural Killer T (NKT) cells and Vδ2  γδ T cells. Accordingly, this study demonstrates that MAIT cells are phenotypically and functionally diverse, that surrogate markers may not reliably identify all of these cells, and that their numbers are regulated in an age-dependent manner and correlate with NKT and Vδ2  γδ T cells.
|mesh-terms=* Aging
* Biomarkers
* Blood Cells
* Cell Differentiation
* Cell Separation
* Cells, Cultured
* Cytokines
* Flow Cytometry
* Histocompatibility Antigens Class I
* Humans
* Lymphocyte Activation
* Minor Histocompatibility Antigens
* Mucosal-Associated Invariant T Cells
* Natural Killer T-Cells
* Receptors, Antigen, T-Cell
* Receptors, Antigen, T-Cell, gamma-delta
* T-Cell Antigen Receptor Specificity
* T-Lymphocyte Subsets
|keywords=* Human immunology
* MAIT
* MR1
* T cell
* unconventional T cell
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6446826
}}