Редактирование: MPZ (раздел)

==Publications==

{{medline-entry
|title=Arrestin and the multi-PDZ domain-containing protein [[MPZ]]-1 interact with phosphatase and tensin homolog (PTEN) and regulate Caenorhabditis elegans longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20207731
|abstract=Arrestins are multifunctional adaptor proteins best known for their role in regulating G protein-coupled receptor signaling. Arrestins also regulate other types of receptors, including the insulin-like growth factor receptor (IGF-1R), although the mechanism by which this occurs is not well understood. In Caenorhabditis elegans, the IGF-1R ortholog DAF-2 regulates dauer formation, stress resistance, metabolism, and lifespan through a conserved signaling cascade. To further elucidate the role of arrestin in IGF-1R signaling, we employed an in vivo approach to investigate the role of ARR-1, the sole arrestin ortholog in C. elegans, on longevity. Here, we report that ARR-1 functions to positively regulate DAF-2 signaling in C. elegans. arr-1 mutant animals exhibit increased longevity and enhanced nuclear localization of DAF-16, an indication of decreased DAF-2 signaling, whereas animals overexpressing ARR-1 have decreased longevity. Genetic and biochemical analysis reveal that ARR-1 functions to regulate DAF-2 signaling via direct interaction with [[MPZ]]-1, a multi-PDZ domain-containing protein, via a C-terminal PDZ binding domain in ARR-1. Interestingly, ARR-1 and [[MPZ]]-1 are found in a complex with the phosphatase and tensin homolog (PTEN) ortholog DAF-18, which normally serves as a suppressor of DAF-2 signaling, suggesting that these three proteins work together to regulate DAF-2 signaling. Our results suggest that the ARR-1-[[MPZ]]-1-DAF-18 complex functions to regulate DAF-2 signaling in vivo and provide insight into a novel mechanism by which arrestin is able to regulate IGF-1R signaling and longevity.
|mesh-terms=* Animals
* Arrestin
* Blotting, Western
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Green Fluorescent Proteins
* Immunoprecipitation
* Longevity
* PTEN Phosphohydrolase
* Receptor, IGF Type 1
* Signal Transduction

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865283
}}