Редактирование: MMP8 (раздел)

==Publications==

{{medline-entry
|title=[Investigation of signal molecules in saliva: prospects of application for diagnostics of myocardial infarction and the aging rate of different age people.]
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31512422
|abstract=Among the diseases of the cardiovascular system in elderly people, ischemic heart disease and myocardial infarction (MI) occupy the first place in the structure of mortality. One of the main causes of disability and death from MI is late diagnosis. In this regard, the search for new, highly informative and non-invasive methods for diagnosing MI is an important task of molecular gerontology. An enzyme immunoassay showed that the concentration of [[TNF]]-α, IL-8 cytokines and p16 aging marker in saliva in elderly people without cardiovascular pathologies ([[CP]]) increases in 2,1-4,8 times as compared with middle-aged people. At the same time, in elderly people without [[CP]] the concentration in the saliva of the hormone irisin ([[FNDC5]]) decreases by 1,8 times as compared with middle-aged people. In middle-aged patients with MI the concentration of IL-8, [[TNF]]-α, [[MMP8]], [[MMP9]] in saliva increases 4,3-15,3 times, and [[FNDC5]] decreases 1,8 times compared with those parameters without [[CP]] in this age group. In elderly people with MI the concentration of IL-8, [[TNF]]-α, [[MMP8]] and [[MMP9]] in saliva increases 4,3-7,1 times as compared with elderly people without [[CP]]. Thus, the study of the concentration of signaling molecules IL-8, [[TNF]]-α, [[MMP8]], [[MMP9]] in saliva can be used as a non-invasive method for diagnosing MI in people of middle and elderly age. To assess the rate of aging of the organism in middle-aged and elderly people without [[CP]], a study of the concentration of p16 and [[FNDC5]] molecules in saliva is recommended.
|mesh-terms=* Aged
* Aging
* Biomarkers
* Cytokines
* Humans
* Middle Aged
* Myocardial Infarction
* Saliva
* Tumor Necrosis Factor-alpha
|keywords=* aging
* diagnosis
* myocardial infarction
* saliva
* signaling molecules

}}
{{medline-entry
|title=Bone biology-related gingival transcriptome in ageing and periodontitis in non-human primates.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26859687
|abstract=Cellular and molecular immunoinflammatory changes in gingival tissues drive alveolar bone loss in periodontitis. Since ageing is a risk factor for periodontitis, we sought to identify age-related gingival transcriptome changes associated with bone metabolism in both healthy and in naturally occurring periodontitis. Adult (12-16 years) and aged (18-23 years) non-human primates (M. mulatta) (n = 24) were grouped into healthy and periodontitis. Gingival tissue samples were obtained and subjected to microarray analysis using the Gene Chip Macaque Genome Array. Gene expression profiles involved in osteoclast/osteoblast proliferation, adhesion and function were evaluated and compared across and between the age groups. QPCR was also performed on selected genes to validate microarray data. Healthy aged tissues showed a gene profile expression that suggest enhancement of osteoclastic adhesion, proliferation/survival and function ([[SPP1]], [[TLR4]], [[MMP8]] and TFEC) and impaired osteoblastic activity (SMEK3P and SMAD5). The gingival transcriptome in both adult and aged animals with naturally occurring periodontitis (FOS, [[IL6]], [[TLR4]], [[MMP9]], [[MMP10]] and [[SPP1]] genes) was consistent with a local inflammatory response driving towards bone/connective tissue destruction. A pro-osteoclastogenic gingival transcriptome is associated with periodontitis irrespective of age; however; a greater bone-destructive molecular environment is associated with ageing in healthy tissues.
|mesh-terms=* Adolescent
* Aging
* Alveolar Bone Loss
* Animals
* Gingiva
* Humans
* Macaca mulatta
* Periodontitis
* Transcriptome
* Young Adult
|keywords=* ageing
* gene expression
* non-human primates
* osteoclast
* periodontitis
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844783
}}