Редактирование: MLST8 (раздел)

==Publications==

{{medline-entry
|title=Genetic variants near [[MLST8]] and [[DHX57]] affect the epigenetic age of the cerebellum.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26830004
|abstract=DNA methylation (DNAm) levels lend themselves for defining an epigenetic biomarker of aging known as the 'epigenetic clock'. Our genome-wide association study (GWAS) of cerebellar epigenetic age acceleration identifies five significant (P<5.0 × 10(-8)) SNPs in two loci: 2p22.1 (inside gene [[DHX57]]) and 16p13.3 near gene [[MLST8]] (a subunit of mTOR complex 1 and 2). We find that the SNP in 16p13.3 has a cis-acting effect on the expression levels of [[MLST8]] (P=6.9 × 10(-18)) in most brain regions. In cerebellar samples, the SNP in 2p22.1 has a cis-effect on [[DHX57]] (P=4.4 × 10(-5)). Gene sets found by our GWAS analysis of cerebellar age acceleration exhibit significant overlap with those of Alzheimer's disease (P=4.4 × 10(-15)), age-related macular degeneration (P=6.4 × 10(-6)), and Parkinson's disease (P=2.6 × 10(-4)). Overall, our results demonstrate the utility of a new paradigm for understanding aging and age-related diseases: it will be fruitful to use epigenetic tissue age as endophenotype in GWAS. 
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Cell Line
* Cerebellum
* Epigenesis, Genetic
* Gene Expression Regulation
* Genetic Variation
* Genome-Wide Association Study
* Humans
* Linkage Disequilibrium
* mTOR Associated Protein, LST8 Homolog

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4740877
}}