Редактирование: MFAP4 (раздел)

==Publications==

{{medline-entry
|title=The role of microfibrillar-associated protein 4 ([[MFAP4]]) in the formation and function of splenic compartments during embryonic and adult life.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26899386
|abstract=Microfibrillar-associated protein 4 ([[MFAP4]]) is an extracellular protein belonging to the fibrinogen-related protein superfamily and is recognized as an integrin ligand with suggested functions in pulmonary and vascular tissue homeostasis. [[MFAP4]] expression in the spleen is increased during infections; however, the significance of [[MFAP4]] for the function of the spleen is unknown. Immunohistochemistry, morphometry and real-time RT-PCR were used to analyze wild-type and [[MFAP4]]-deficient spleens. In addition, they were compared with splenic tissue, which was newly formed 8 weeks after avascular implantation into adult mice in order to obtain information about the role of [[MFAP4]] in the formation of splenic tissue during ontogeny and adult life. The present study shows that [[MFAP4]] is co-localized with laminin in the B- and T-cell zones of the spleen, in addition to capsular and trabecular expression. [[MFAP4]] is most likely produced by fibroblastic reticulum cells and follicular dendritic cells of the spleen but can also be imported via the blood from other tissues. The development of splenic tissue is not disturbed in [[MFAP4]]-deficient mice. However, in splenic tissue regenerating under [[MFAP4]]-deficient conditions, the number of FDCs is significantly decreased but is corrected by [[MFAP4]] imported from other tissues. No differences were observed for lymphocyte numbers or splenic structure. The data indicate that [[MFAP4]] promotes FDC development in regenerating splenic tissue and warrant further investigations regarding the [[MFAP4]] dependency of splenic B-cell maturation.
|mesh-terms=* Aging
* Animals
* B-Lymphocytes
* Carrier Proteins
* Cell Proliferation
* Embryo, Mammalian
* Extracellular Matrix Proteins
* Female
* Germinal Center
* Glycoproteins
* Laminin
* Mice, Inbred C57BL
* Regeneration
* Spleen
* T-Lymphocytes
|keywords=* Development
* Mice
* Regeneration
* Splenic tissue
* Transplantation
|full-text-url=https://sci-hub.do/10.1007/s00441-016-2374-1
}}