Редактирование: MED1 (раздел)

==Publications==

{{medline-entry
|title=Mediator subunits [[MED1]] and [[MED24]] cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22331469
|abstract=The Mediator subunit [[MED1]] is essential for mammary gland development and lactation, whose contribution through direct interaction with estrogen receptors (ERs) is restricted to involvement in pubertal mammary gland development and luminal cell differentiation. Here, we provide evidence that the [[MED24]]-containing submodule of Mediator functionally communicates specifically with [[MED1]] in pubertal mammary gland development. Mammary glands from [[MED1]]/[[MED24]] double heterozygous knockout mice showed profound retardation in ductal branching during puberty, while single haploinsufficient glands developed normally. DNA synthesis of both luminal and basal cells were impaired in double mutant mice, and the expression of ER-targeted genes encoding [[E2F1]] and cyclin D1, which promote progression through the G(1)/S phase of the cell cycle, was attenuated. Luciferase reporter assays employing double mutant mouse embryonic fibroblasts showed selective impairment in ER functions. Various breast carcinoma cell lines expressed abundant amounts of [[MED1]], [[MED24]], and [[MED30]], and attenuated expression of [[MED1]] and [[MED24]] in breast carcinoma cells led to attenuated DNA synthesis and growth. These results indicate functional communications between the [[MED1]] subunit and the [[MED24]]-containing submodule that mediate estrogen receptor functions and growth of both normal mammary epithelial cells and breast carcinoma cells.
|mesh-terms=* Aging
* Animals
* Breast Neoplasms
* Cell Line, Tumor
* Cyclin D1
* E2F1 Transcription Factor
* Female
* G1 Phase
* Humans
* Mammary Glands, Animal
* Mammary Neoplasms, Animal
* Mediator Complex
* Mediator Complex Subunit 1
* Mice
* S Phase

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318591
}}