Редактирование: MECOM (раздел)

==Publications==

{{medline-entry
|title=Clinical and genetic risk factors for decreased bone mineral density in Japanese patients with inflammatory bowel disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29603369
|abstract=Patients with inflammatory bowel disease (IBD) are at a high risk of low bone mineral density (BMD). Reportedly, clinical and genetic factors cause low BMD in Caucasians; however, studies in non-Caucasian populations remain scarce. Clinical risk factors for low BMD were investigated in 266 Japanese patients with IBD, and a genome-wide association analysis (GWAS) was performed using linear regression with associated clinical factors as covariates. Genotyping was performed using a population-optimized genotyping array (Japonica array  ). After quality control, the genotype data of 4 384 682 single-nucleotide polymorphisms (SNPs) from 254 patients with IBD were used for GWAS. Body mass index, age, and disease duration were independently associated with the BMD of the femoral neck (P = 1.41E - 13, 1.04E - 5, and 1.58E - 3, respectively), and body mass index and sex were associated with the BMD of the lumbar spine (P = 6.90E - 10 and 6.84E - 3, respectively). In GWAS, 118 and 42 candidate SNPs of the femoral neck and lumbar spine, respectively, were identified. Among 118, 111 candidate SNPs of the femoral neck were located within the [[SLC22A23]] gene, which is a known IBD susceptibility gene (minimum P = 1.42E - 07). Among 42, 18 candidate SNPs of the lumbar spine were located within the [[MECOM]] gene, which is associated with osteopenia (minimum P = 5.86E - 07). Interestingly, none of the known loci showed a significant association with BMD. Although clinical risk factors for low BMD in IBD were similar to those in the general population, genetic risk factors were rather different.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Asian Continental Ancestry Group
* Body Mass Index
* Bone Density
* Bone Diseases, Metabolic
* Female
* Femur Neck
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Genotype
* Humans
* Inflammatory Bowel Diseases
* Lumbar Vertebrae
* MDS1 and EVI1 Complex Locus Protein
* Male
* Middle Aged
* Organic Anion Transporters
* Polymorphism, Single Nucleotide
* Risk Factors
* Sex Characteristics
* Young Adult
|keywords=* genome-wide association analysis
* inflammatory bowel disease genetics
* osteoporosis
|full-text-url=https://sci-hub.do/10.1111/jgh.14149
}}