Редактирование: MAPK11 (раздел)

==Publications==

{{medline-entry
|title=lncRNA ENSMUST00000134285 Increases [[MAPK11]] Activity, Regulating Aging-Related Myocardial Apoptosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29415197
|abstract=Previous studies have demonstrated that aging promotes myocardial apoptosis after ischemia/reperfusion, via unknown specific mechanisms. The present study investigates the potential relationship between lncRNAs and aging-related apoptosis by lncRNA/mRNA microarray technology. The results indicate aging increased myocardial lncRNA ENSMUST00000134285 and m[[MAPK11]], confirmed by both bioinformatics analysis and polymerase chain reaction (PCR). Mouse cardiomyocytes were subjected to gene manipulation (ENSMUST00000134285 knockdown and overexpression). Knockdown of ENSMUST00000134285 inhibited [[MAPK11]] activity and increased the myocardial apoptotic ratio (determined by TUNEL staining and caspase activity assays) after hypoxia/reoxygenation. Conversely, overexpression of ENSMUST00000134285 increased [[MAPK11]] activity and decreased the myocardial apoptotic ratio. Furthermore, luciferase reporter assay revealed that miR760 may be a mediator between ENSMUST00000134285 and m[[MAPK11]]. We have provided evidence that lncRNAs are the important regulatory molecules in aging-mediated effects upon apoptosis. The apoptosis regulatory effects of aging are complex. Except apoptosis-promoting effects, aging could also inhibit myocardial apoptosis after hypoxia or ischemia. Further studies investigating the mechanisms that aging inhibit myocardial apoptosis after hypoxia/ischemia.
|mesh-terms=* Aging
* Animals
* Apoptosis
* Blotting, Western
* Mice
* Mitogen-Activated Protein Kinase 11
* Myocardium
* Myocytes, Cardiac
* Oligonucleotide Array Sequence Analysis
* RNA, Long Noncoding
* Real-Time Polymerase Chain Reaction

|full-text-url=https://sci-hub.do/10.1093/gerona/gly020
}}