Редактирование: KDR (раздел)

==Publications==

{{medline-entry
|title=Regulation of endothelial progenitor cell differentiation and function by dimethylarginine dimethylaminohydrolase 2 in an asymmetric dimethylarginine-independent manner.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24764313
|abstract=Endothelial progenitor cells (EPCs) are involved in the repair of vessels and angiogenesis and are useful in the treatment of ischemic diseases. The dimethylarginine dimethylaminohydrolase (DDAH)/asymmetric dimethylarginine (ADMA) pathway is regulated by silent information regulator 1 ([[SIRT1]]), leading to the senescence of endothelial cells (ECs). Here, we demonstrated that peripheral blood EPCs predominantly expressed [[DDAH2]] that increased with EPC differentiation. EPC senescence and dysfunction were induced on interruption of [[DDAH2]] expression, whereas the mRNA expression of vascular endothelial growth factor (VEGF) and kinase-domain insert containing receptor ([[KDR]]) were downregulated. Moreover, [[SIRT1]] expression increased with EPC differentiation. Interruption of [[SIRT1]] inhibited [[DDAH2]], VEGF, and [[KDR]] expression, but had no effect on the level of ADMA. From our data, we concluded that [[DDAH2]] is involved in the differentiation of EPCs and regulates the senescence and function of EPCs through the VEGF/[[KDR]] pathway by activation of [[SIRT1]]. 
|mesh-terms=* Amidohydrolases
* Arginine
* Cell Differentiation
* Cells, Cultured
* Cellular Senescence
* Endothelial Progenitor Cells
* Humans
* RNA Interference
* RNA, Messenger
* RNA, Small Interfering
* Sirtuin 1
* Vascular Endothelial Growth Factor A
* Vascular Endothelial Growth Factor Receptor-2
|keywords=* SIRT1
* dimethylarginine dimethylaminohydrolase
* endothelial progenitor cells
* senescence
|full-text-url=https://sci-hub.do/10.1002/cbin.10288
}}