Редактирование: HSPA14 (раздел)

==Publications==

{{medline-entry
|title=Evidence from case-control and longitudinal studies supports associations of genetic variation in [[APOE]], [[CETP]], and [[IL6]] with human longevity.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22234866
|abstract=In this study, we investigated 102 single-nucleotide polymorphisms (SNPs) covering the common genetic variation in 16 genes recurrently regarded as candidates for human longevity: [[APOE]]; ACE; [[CETP]]; HFE; [[IL6]]; [[IL6]]R; MTHFR; TGFB1; APOA4; APOC3; SIRTs 1, 3, 6; and HSPAs 1A, 1L, 14. In a case-control study of 1,089 oldest-old (ages 92-93) and 736 middle-aged Danes, the minor allele frequency ([[MAF]]) of rs769449 ([[APOE]]) was significantly decreased in the oldest-old, while the [[MAF]] of rs9923854 ([[CETP]]) was significantly enriched. These effects were supported when investigating 1,613 oldest-old (ages 95-110) and 1,104 middle-aged Germans. rs769449 was in modest linkage equilibrium (R (2)=0.55) with rs429358 of the [[APOE]]-ε4 haplotype and adjusting for rs429358 eliminated the association of rs769449, indicating that the association likely reflects the well-known effect of rs429358. Gene-based analysis confirmed the effects of variation in [[APOE]] and [[CETP]] and furthermore pointed to [[HSPA14]] as a longevity gene. In a longitudinal study with 11 years of follow-up on survival in the oldest-old Danes, only one SNP, rs2069827 ([[IL6]]), was borderline significantly associated with survival from age 92 (P-corrected=0.064). This advantageous effect of the minor allele was supported when investigating a Dutch longitudinal cohort (N=563) of oldest-old (age 85 ). Since rs2069827 was located in a putative transcription factor binding site, quantitative RNA expression studies were conducted. However, no difference in [[IL6]] expression was observed between rs2069827 genotype groups. In conclusion, we here support and expand the evidence suggesting that genetic variation in [[APOE]], [[CETP]], and [[IL6]], and possible [[HSPA14]], is associated with human longevity.
|mesh-terms=* Aged, 80 and over
* Alleles
* Apolipoproteins E
* Case-Control Studies
* Cholesterol Ester Transfer Proteins
* Denmark
* Female
* Gene Frequency
* Genetic Variation
* Genotype
* Germany
* Haplotypes
* Humans
* Interleukin-6
* Linear Models
* Longevity
* Longitudinal Studies
* Male
* Middle Aged
* Netherlands
* Polymorphism, Single Nucleotide
* Registries

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3592963
}}