Редактирование: HPGDS (раздел)

==Publications==

{{medline-entry
|title=Hematopoietic prostaglandin D synthase is expressed in microglia in the developing postnatal mouse brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/12673832
|abstract=Hematopoietic prostaglandin D synthase ([[HPGDS]]) is a PGD(2)-synthesizing enzyme and is expressed in antigen-presenting cells, mast cells, and other immunocompetent cells. We here report the [[HPGDS]] expression in microglia and the migration pathway of microglia in the developing mouse brain as detected by [[HPGDS]] immunohistochemistry. Expression of [[HPGDS]] mRNA peaked at postnatal day (PND) 10, decreased gradually thereafter, and reached a plateau at PND 20. The mRNAs for target molecules of PGD(2), i.e., DP receptor (DPR) and CRTH2 receptor, showed developmental profiles overlapped to that of [[HPGDS]]. Most of the [[HPGDS]]( ) cells at PND 10 had morphological characteristics of ameboid microglia and gave positive immunostaining with microglia-specific markers such as RCA-1, F4/80, or ER-MP12. These specific markers became less detectable later on, but [[HPGDS]] was still expressed even in resting microglia. Thus, [[HPGDS]] is a useful marker for investigation of microglial development. Spaciotemporal evaluation of microglial development and migration with [[HPGDS]] immunostaining revealed the following three major possible migration pathways of microglia in the postnatal brain: from the lateral ventricle via subventricular zones to brain parenchyma; from the leptomeninges around the cerebellopontine angle to the cerebellar white matter; and from the overlying leptomeninges to the hippocampus, basal forebrain, and brainstem.
|mesh-terms=* Aging
* Animals
* Animals, Newborn
* Antigens, Differentiation
* Biomarkers
* Brain
* Cell Differentiation
* Cell Movement
* Cell Size
* Female
* Gene Expression Regulation, Developmental
* Immunohistochemistry
* Intramolecular Oxidoreductases
* Lipocalins
* Male
* Mice
* Mice, Inbred C57BL
* Mice, Knockout
* Microglia
* Platelet Endothelial Cell Adhesion Molecule-1
* Prostaglandin D2
* RNA, Messenger
* Receptors, Cytoplasmic and Nuclear
* Receptors, Immunologic
* Receptors, Prostaglandin
* Transcription Factors

|full-text-url=https://sci-hub.do/10.1002/glia.10183
}}