Редактирование: GRK3 (раздел)

==Publications==

{{medline-entry
|title=Alterations of epinephrine-induced gluconeogenesis in aging.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/19307753
|abstract=The effects of glucagon and epinephrine on gluconeogenesis in young (4 month) and old (24 month) Fisher 344 rat hepatocytes were compared. In contrast to glucagon, which had a similar effect on gluconeogenesis in both young and old cells, epinephrine caused a smaller increase in gluconeogenesis in old rat hepatocytes than in young hepatocytes. beta2 adrenergic receptor (beta2-[[AR]]) expression slightly decreased in aged rat liver, and there were differences between young and old hepatocytes in their patterns of G protein coupled receptor kinases, which are involved in the activation of beta2-[[AR]] receptor signal desensitization. The major isoform of the kinase changed from [[GRK2]] to [[GRK3]] and the expression of beta-arrestin, which is recruited by the phosphorylated beta2-[[AR]] for internalization and degradation, increased in aged rat liver. [[GRK3]] overexpression also decreased the glucose output from young rat hepatocytes. We conclude that an age-associated reduction in epinephrine-induced gluconeogenesis occurs through the epinephrine receptor desensitizing system.
|mesh-terms=* Adrenergic beta-2 Receptor Agonists
* Adrenergic beta-Agonists
* Aging
* Animals
* Epinephrine
* G-Protein-Coupled Receptor Kinase 2
* G-Protein-Coupled Receptor Kinase 3
* Glucagon
* Gluconeogenesis
* Male
* Models, Biological
* Phosphorylation
* Rats
* Rats, Inbred F344
* Receptors, Adrenergic, beta-2

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2701982
}}