Редактирование: GFRA2 (раздел)

==Publications==

{{medline-entry
|title=Glial cell line-derived neurotrophic factor receptor alpha 2 ([[GFRA2]]) gene is associated with tardive dyskinesia.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20369355
|abstract=Tardive dyskinesia (TD) has a pharmacogenetic component in which the interaction of antipsychotic exposure with individual genetic variation mediates risk. The glial cell line-derived neurotrophic factor ([[GDNF]]) signalling pathway has been associated with neuroprotective effects in central dopaminergic neurons and spinal motor neurons. Clinical trials have also investigated whether [[GDNF]] may ameliorate Parkinson's disease symptoms. We tested whether variants in the [[GDNF]] receptor alpha 2 ([[GFRA2]]) gene could play a role in TD susceptibility evaluating 16 variants in 172 Caucasian schizophrenia subjects. We observed one significant allelic association (rs4739285, permuted p = 0.042) and two genotypic associations: rs4739285 under additive inheritance model and rs4739217 under dominant inheritance model (permuted p = 0.044). Moreover, carriers of the major alleles for both rs6587002 and rs4739217 presented significantly higher risk for TD (OR = 2.04, permuted p = 0.014), while subjects with the minor allele for rs4739217 and the major allele for rs6988470 were less likely to have TD (OR = 0.21, permuted p = 0.0007). Haplotype results indicate that the minor allele of the rs4739217 is a risk factor for TD (permuted allelic p = 0.074). Age was also a risk factor for TD in our sample (p = 0.0001). Taken together, our findings suggest that [[GFRA2]] genetic variants and age may play a role in TD susceptibility, but further work is required to confirm these findings.
|mesh-terms=* Adult
* Aging
* Alleles
* Antipsychotic Agents
* Dyskinesia, Drug-Induced
* Female
* Genetic Predisposition to Disease
* Genetic Variation
* Genotype
* Glial Cell Line-Derived Neurotrophic Factor Receptors
* Haplotypes
* Humans
* Male
* Middle Aged
* Risk Factors
* Schizophrenia

|full-text-url=https://sci-hub.do/10.1007/s00213-010-1829-4
}}