Редактирование: GCG (раздел)

==Publications==

{{medline-entry
|title=Apolipoprotein E and longevity among Han Chinese population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/9792194
|abstract=The apolipoprotein E gene ([[APOE]]), which locates on chromosome 19, has three common [[APOE]] alleles encoding [[APOE]]*2, [[APOE]]*3, [[APOE]]*4. It has been considered to be closely associated with human longevity among Western population. However, the allele frequency varies among racial and ethnic groups. We studied the relationship between [[APOE]] and longevity among 1562 Han Chinese (246 female and 1316 male) whose ages ranged from 20-108 years old in Shanghai metropolitan area and Lian Yungang, Jiangsu province. [[APOE]] was amplified by one-stage PCR using the forward primer: 5'-GGC ACG GCT GTC CAA GGA GCT-3' and reverse primer: 5'-GAT GGC GCT GAG GCC [[GCG]] CT-3'. The PCR product was digested directly with 5 U of CfoI and separated by a 20% polyacrylamide (acrylamide:bisacrylamide = 29:1) nondenaturing gel. The allele frequency of [[APOE]]*4 in thevery old age group (> or = 85 years) was significantly different from that in the youth (20-39 years), middle (40-59 years) and old (60-84 years) age group (2.5% vs 8.4, 7.9 or 7.6%; P < 0.05), respectively.
|mesh-terms=* Adult
* Age Distribution
* Aged
* Aged, 80 and over
* Alleles
* Apolipoproteins E
* Asian Continental Ancestry Group
* Female
* Gene Frequency
* Genotype
* Humans
* Longevity
* Male
* Middle Aged
* Sex Distribution

|full-text-url=https://sci-hub.do/10.1016/s0047-6374(98)00067-0
}}
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