Редактирование: FGG (раздел)

==Publications==

{{medline-entry
|title=Candidate SNP associations of optimism and resilience in older adults: exploratory study of 935 community-dwelling adults.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24791650
|abstract=Optimism and resilience promote health and well-being in older adults, and previous reports suggest that these traits are heritable. We examined the association of selected single-nucleotide polymorphisms (SNPs) with optimism and resilience in older adults. Candidate gene association study that was a follow-on at the University of California, San Diego, sites of two NIH-funded multi-site longitudinal investigations: Women's Health Initiative (WHI) and SELenium and vitamin E Cancer prevention Trial (SELECT). 426 women from WHI older than age 50 years, and 509 men older than age 55 years (age 50 years for African American men) from SELECT. 65 candidate gene SNPs that were judged by consensus, based on a literature review, as being related to predisposition to optimism and resilience, and 31 ancestry informative marker SNPs, genotyped from blood-based DNA samples and self-report scales for trait optimism, resilience, and depressive symptoms. Using a Bonferroni threshold for significant association (p = 0.00089), there were no significant associations for individual SNPs with optimism or resilience in single-locus analyses. Exploratory multi-locus polygenic analyses with p <0.05 showed an association of optimism with SNPs in [[MAOA]], [[IL10]], and [[FGG]] genes, and an association of resilience with a SNP in [[MAOA]] gene. Correcting for Type I errors, there were no significant associations of optimism and resilience with specific gene SNPs in single-locus analyses. Positive psychological traits are likely to be genetically complex, with many loci having small effects contributing to phenotypic variation. Our exploratory multi-locus polygenic analyses suggest that larger sample sizes and complementary approaches involving methods such as sequence-based association studies, copy number variation analyses, and pathway-based analyses could be useful for better understanding the genetic basis of these positive psychological traits.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Depression
* European Continental Ancestry Group
* Female
* Fibrinogens, Abnormal
* Genetic Association Studies
* Genotype
* Humans
* Interleukin-10
* Male
* Middle Aged
* Monoamine Oxidase
* Multifactorial Inheritance
* Personality
* Polymorphism, Single Nucleotide
* Resilience, Psychological
|keywords=* Optimism
* aging
* depression
* genotyping
* resilience
* single-nucleotide polymorphisms
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163500
}}
{{medline-entry
|title=A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23650146
|abstract=Venous thromboembolism (VTE) is a common, heritable disease resulting in high rates of hospitalization and mortality. Yet few associations between VTE and genetic variants, all in the coagulation pathway, have been established. To identify additional genetic determinants of VTE, we conducted a two-stage genome-wide association study (GWAS) among individuals of European ancestry in the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) VTE consortium. The discovery GWAS comprised 1,618 incident VTE cases out of 44,499 participants from six community-based studies. Genotypes for genome-wide single-nucleotide polymorphisms (SNPs) were imputed to approximately 2.5 million SNPs in HapMap and association with VTE assessed using study-design appropriate regression methods. Meta-analysis of these results identified two known loci, in [[F5]] and [[ABO]]. Top 1,047 tag SNPs (P ≤ 0.0016) from the discovery GWAS were tested for association in an additional 3,231 cases and 3,536 controls from three case-control studies. In the combined data from these two stages, additional genome-wide significant associations were observed on 4q35 at [[F11]] (top SNP rs4253399, intronic to [[F11]]) and on 4q28 at [[FGG]] (rs6536024, 9.7 kb from [[FGG]]; P < 5.0 × 10(-13) for both). The associations at the [[FGG]] locus were not completely explained by previously reported variants. Loci at or near [[SUSD1]] and [[OTUD7A]] showed borderline yet novel associations (P < 5.0 × 10(-6) ) and constitute new candidate genes. In conclusion, this large GWAS replicated key genetic associations in [[F5]] and [[ABO]], and confirmed the importance of [[F11]] and [[FGG]] loci for VTE. Future studies are warranted to better characterize the associations with [[F11]] and [[FGG]] and to replicate the new candidate associations.
|mesh-terms=* Aged
* Aging
* Case-Control Studies
* Cohort Studies
* Female
* Genome-Wide Association Study
* Humans
* Male
* Meta-Analysis as Topic
* Middle Aged
* Polymorphism, Single Nucleotide
* Regression Analysis
* Risk Factors
* Venous Thromboembolism

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3990406
}}