Редактирование: FEZ1 (раздел)

==Publications==

{{medline-entry
|title=Disruption to schizophrenia-associated gene Fez1 in the hippocampus of [[HDAC11]] knockout mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28928414
|abstract=Histone Deacetylase 11 ([[HDAC11]]) is highly expressed in the central nervous system where it has been reported to have roles in neural differentiation. In contrast with previous studies showing nuclear and cytoplasmic localisation, we observed synaptic enrichment of [[HDAC11]]. Knockout mouse models for HDACs 1-9 have been important for guiding the development of isoform specific HDAC inhibitors as effective therapeutics. Given the close relationship between [[HDAC11]] and neural cells in vitro, we examined neural tissue in a previously uncharacterised Hdac11 knockout mouse (Hdac11  ). Loss of [[HDAC11]] had no obvious impact on brain morphology and neural stem/precursor cells isolated from Hdac11   mice had comparable proliferation and differentiation characteristics. However, in differentiating neural cells we observed decreased expression of schizophrenia-associated gene Fez1 (fasciculation and elongation protein zeta 1), a gene previously reported to be regulated by [[HDAC11]] activity. [[FEZ1]] has been associated with the dendritic growth of neurons and risk of schizophrenia via its interaction with [[DISC1]] (disrupted in schizophrenia 1). Examination of cortical, cerebellar and hippocampal tissue reveal decreased Fez1 expression specifically in the hippocampus of adult mice. The results of this study demonstrate that loss of [[HDAC11]] has age dependent and brain-region specific consequences.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Aging
* Animals
* Cell Line
* Gene Expression Regulation
* Hippocampus
* Histone Deacetylases
* Mice
* Mice, Knockout
* Nerve Tissue Proteins
* Neural Stem Cells
* Neurogenesis
* Schizophrenia

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605701
}}