Редактирование: FBXO7 (раздел)

==Publications==

{{medline-entry
|title=The [[FBXO7]] homologue nutcracker and binding partner PI31 in Drosophila melanogaster models of Parkinson's disease.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27936908
|abstract=Parkinsonian-pyramidal syndrome (PPS) is an early onset form of Parkinson's disease (PD) that shows degeneration of the extrapyramidal region of the brain to result in a severe form of PD. The toxic protein build-up has been implicated in the onset of PPS. Protein removal is mediated by an intracellular proteasome complex: an E3 ubiquitin ligase, the targeting component, is essential for function. [[FBXO7]] encodes the F-box component of the SCF E3 ubiquitin ligase linked to familial forms of PPS. The Drosophila melanogaster homologue nutcracker (ntc) and a binding partner, PI31, have been shown to be active in proteasome function. We show that altered expression of either ntc or PI31 in dopaminergic neurons leads to a decrease in longevity and locomotor ability, phenotypes both associated with models of PD. Furthermore, expression of ntc-RNAi in an established α-synuclein-dependent model of PD rescues the phenotypes of diminished longevity and locomotor control.
|mesh-terms=* Animals
* Animals, Genetically Modified
* Carrier Proteins
* Disease Models, Animal
* Drosophila Proteins
* Drosophila melanogaster
* Eye
* F-Box Proteins
* Female
* Gene Expression
* Longevity
* Male
* Organ Specificity
* Organogenesis
* Parkinson Disease
* Protein Binding
* Protein Interaction Domains and Motifs
* alpha-Synuclein
|keywords=* Drosophila melanogaster
* FBXO7
* PI31
* Parkinson Disease
* maladie de Parkinson
* neurodegeneration
* neurodégénérescence
* nutcracker
|full-text-url=https://sci-hub.do/10.1139/gen-2016-0087
}}