Редактирование: ETNK2 (раздел)

==Publications==

{{medline-entry
|title=In silico analysis of human renin gene-gene interactions and neighborhood topologically associated domains suggests breakdown of insulators contribute to ageing-associated diseases.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31520345
|abstract=Three-dimensional chromatin architecture and gene-gene interactions impact gene expression. We assembled this information, in silico, for the human renin gene ([[REN]]). We searched for chromatin contacts and boundaries and the locations of super-enhancers that are involved in cell specific differentiation. The [[REN]] promoter was connected via RNA polymerase II binding to promoters of 12 neighboring genes on chromosome 1q32.1 over a distance of 762,497 bp. This constitutes a regulatory archipelago. The genes formed 3 topologically associated domains (TADs), as follows: TAD1: [[ZC3H11A]], [[SNRPE]], LINC00303; [[SOX13]]; TAD2: [[ETNK2]], [[REN]], [[KISS1]], GOLT1A; TAD3: [[PLEKHA6]], LINC00628, [[PPP1R15B]], [[PIK3C2B]], [[MDM4]]. [[REN]] in TAD2, was isolated from its neighboring genes in TAD1 and TAD3 by [[CTCF]]-binding sites that serve as insulators. TAD1 and TAD3 genes [[SOX13]] and LINC00628 overlapped super-enhancers, known to reside near nodes regulating cell identity, and were co-expressed in various tissues, suggesting co-regulation. [[REN]] was also connected with 62 distant genes genome-wide, including the angiotensin II type 1 receptor gene. The findings lead us to invoke the following novel hypothesis. While the [[REN]] promoter is isolated from neighboring super-enhancers in most cells by insulators, these insulators break down with cell age to permit the inappropriate expression of [[REN]] in non-kidney cells by using the neighboring super-enhancers, resulting in expression in a wider spectrum of tissues, contributing to aging-related immune system dysregulation, cardiovascular diseases and cancers. Research is needed to confirm this hypothesis experimentally.
|mesh-terms=* Aging
* Computer Simulation
* Epistasis, Genetic
* Humans
* Promoter Regions, Genetic
* Renin
|keywords=* Aging
* Diseases of aging
* Gene expression
* Gene–gene interaction
* Genomics
* Longevity
* Renin-angiotensin system
* Topologically associated domains
|full-text-url=https://sci-hub.do/10.1007/s10522-019-09834-1
}}