Редактирование: ESRG (раздел)

==Publications==

{{medline-entry
|title=[[MYC]] Releases Early Reprogrammed Human Cells from Proliferation Pause via Retinoblastoma Protein Inhibition.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29641997
|abstract=Here, we report that [[MYC]] rescues early human cells undergoing reprogramming from a proliferation pause induced by OCT3/4, [[SOX2]], and [[KLF4]] (OSK). We identified [[ESRG]] as a marker of early reprogramming cells that is expressed as early as day 3 after OSK induction. On day 4, [[ESRG]] positive ( ) cells converted to a [[[[TRA]]]]-1-60 ( ) intermediate state. These early [[ESRG]] ( ) or [[[[TRA]]]]-1-60 ( ) cells showed a proliferation pause due to increased p16INK4A and p21 and decreased endogenous [[MYC]] caused by OSK. Exogenous [[MYC]] did not enhance the appearance of initial reprogramming cells but instead reactivated their proliferation and improved reprogramming efficiency. [[MYC]] increased expression of LIN41, which potently suppressed p21 post-transcriptionally. [[MYC]] suppressed p16 INK4A. These changes inactivated retinoblastoma protein (RB) and reactivated proliferation. The RB-regulated proliferation pause does not occur in immortalized fibroblasts, leading to high reprogramming efficiency even without exogenous [[MYC]].
|mesh-terms=* Antigens, Surface
* Cell Line
* Cell Proliferation
* Cellular Reprogramming
* Cyclin-Dependent Kinase Inhibitor p16
* Humans
* Induced Pluripotent Stem Cells
* Phosphorylation
* Proteoglycans
* Proto-Oncogene Proteins c-myc
* RNA Interference
* RNA, Small Interfering
* Retinoblastoma Protein
* Transcription Factors
* Tripartite Motif Proteins
* Ubiquitin-Protein Ligases
|keywords=* LIN41
* MYC
* immortalization
* induced pluripotent stem cell
* pluripotency
* post-transcriptional regulation
* proliferation
* reprogramming
* senescence
|full-text-url=https://sci-hub.do/10.1016/j.celrep.2018.03.057
}}