Редактирование: ENTPD1 (раздел)

==Publications==

{{medline-entry
|title=Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32452837
|abstract=Vaccination is a mainstay in preventive medicine, reducing morbidity and mortality from infection, largely by generating pathogen-specific neutralizing antibodies. However, standard immunization strategies are insufficient with increasing age due to immunological impediments, including defects in T follicular helper (Tfh) cells. Here, we found that Tfh generation is inversely linked to the expression of the ecto-NTPDase CD39 that modifies purinergic signaling. The lineage-determining transcription factor [[BCL6]] inhibited CD39 expression, while increased Tfh frequencies were found in individuals with a germline polymorphism preventing transcription of [[ENTPD1]], encoding CD39. In in vitro human and in vivo mouse studies, Tfh generation and germinal center responses were enhanced by reducing CD39 expression through the inhibition of the cAMP/PKA/p-CREB pathway, or by blocking adenosine signaling downstream of CD39 using the selective adenosine A2a receptor antagonist istradefylline. Thus, purinergic signaling in differentiating T cells can be targeted to improve vaccine responses, in particular in older individuals who have increased CD39 expression.

|keywords=* Adaptive immunity
* Aging
* Cellular senescence
* T cells
* Vaccines
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7324201
}}