Редактирование: ELOVL6 (раздел)

==Publications==

{{medline-entry
|title=An Adult Drosophila Glioma Model for Studying Pathometabolic Pathways of Gliomagenesis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30357574
|abstract=Glioblastoma multiforme (GBM), the most prevalent brain tumor in adults, has extremely poor prognosis. Frequent genetic alterations that activate epidermal growth factor receptor ([[EGFR]]) and phosphatidylinositol-3 kinase (PI3K) signaling, as well as metabolic remodeling, have been associated with gliomagenesis. To establish a whole-animal approach that can be used to readily identify individual pathometabolic signaling factors, we induced glioma formation in the adult Drosophila brain by activating the [[EGFR]]-PI3K pathway. Glioma-induced animals showed significantly enlarged brain volume, early locomotor abnormalities, memory deficits, and a shorter lifespan. Combining bioinformatics analysis and glial-specific gene knockdown in the adult fly glioma model, we identified four evolutionarily conserved metabolic genes, including [[ALDOA]], [[ACAT1]], [[ELOVL6]], and [[LOX]], that were involved in gliomagenesis. Silencing of [[ACAT1]], which controls cholesterol homeostasis, reduced brain enlargement and increased the lifespan of the glioma-bearing flies. In GBM patients, [[ACAT1]] is overexpressed and correlates with poor survival outcomes. Moreover, pharmacological inhibition of [[ACAT1]] in human glioma cell lines revealed that it is essential for tumor proliferation. Collectively, these results imply that [[ACAT1]] is a potential therapeutic target, and cholesterol homeostasis is strongly related to glioma formation. This in vivo model provides several rapid and robust phenotypic readouts, allowing determination of the pathometabolic pathways involved in gliomagenesis, as well as providing valuable information for novel therapeutic strategies.
|mesh-terms=* Aging
* Animals
* Behavior, Animal
* Brain Neoplasms
* Carcinogenesis
* Cell Line, Tumor
* Cell Survival
* Disease Models, Animal
* Drosophila melanogaster
* Gene Expression Regulation, Neoplastic
* Glioma
* Humans
* Longevity
* Memory Disorders
* Metabolic Networks and Pathways
* Motor Activity
* Sterol O-Acyltransferase
* Survival Analysis
|keywords=* ACAT1
* Drosophila
* Glioma
* Metabolism
|full-text-url=https://sci-hub.do/10.1007/s12035-018-1392-2
}}