Редактирование: ELK1 (раздел)

==Publications==

{{medline-entry
|title=Tocotrienol-rich fraction prevents cellular aging by modulating cell proliferation signaling pathways.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25945449
|abstract=Vitamin E has been suggested as nutritional intervention for the prevention of degenerative and age-related diseases. In this study, we aimed to elucidate the underlying mechanism of tocotrienol-rich fraction (TRF) in delaying cellular aging by targeting the proliferation signaling pathways in human diploid fibroblasts (HDFs). Tocotrienol-rich fraction was used to treat different stages of cellular aging of primary human diploid fibroblasts viz. young (passage 6), pre-senescent (passage 15) and senescent (passage 30). Several selected targets involved in the downstream of PI3K/AKT and RAF/MEK/ERK pathways were compared in total RNA and protein. Different transcriptional profiles were observed in young, pre-senescent and senescent HDFs, in which cellular aging increased AKT, [[FOXO3]], [[CDKN1A]] and RSK1 mRNA expression level, but decreased [[ELK1]], [[FOS]] and [[SIRT1]] mRNA expression level. With tocotrienol-rich fraction treatment, gene expression of AKT, [[FOXO3]], ERK and RSK1 mRNA was decreased in senescent cells, but not in young cells. The three down-regulated mRNA in cellular aging, [[ELK1]], [[FOS]] and [[SIRT1]], were increased with tocotrienol-rich fraction treatment. Expression of [[FOXO3]] and P21Cip1 proteins showed up-regulation in senescent cells but tocotrienol-rich fraction only decreased P21Cip1 protein expression in senescent cells. Tocotrienol-rich fraction exerts gene modulating properties that might be responsible in promoting cell cycle progression during cellular aging.
|mesh-terms=* Antioxidants
* Cell Proliferation
* Cells, Cultured
* Cellular Senescence
* Diploidy
* Fibroblasts
* Humans
* Tocotrienols
* Vitamin E
|keywords=* Cellular aging
* Gene expression
* Human diploid fibroblasts
* Tocotrienol-rich fraction
* Vitamin E
|full-text-url=https://sci-hub.do/10.7417/CT.2015.1825
}}