Редактирование: EDNRA (раздел)

==Publications==

{{medline-entry
|title=Variation in genes in the endothelin pathway and endothelium-dependent and endothelium-independent vasodilation in an elderly population.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23336501
|abstract=Indirect evidences by blockade of the endothelin receptors have suggested a role of endothelin in endothelium-dependent vasodilation. This study aimed to investigate whether circulating levels of endotehlin-1 or genetic variations in genes in the endothelin pathway were related to endothelium-dependent vasodilation. In 1016 seventy-year-old participants of the population-based Prospective Study of the Vasculature in Uppsala Seniors (PIVUS) study (52% women), we measured endothelium-dependent vasodilation using the invasive forearm technique with acetylcholine given in the brachial artery (EDV) and the brachial artery ultrasound technique with measurement of flow-mediated dilatation (FMD). Plasma endothelin-1 levels were measured and 60 SNPs in genes in the endothelin pathway (ECE1, [[EDN1]], [[EDNRA]], [[EDNRB]]) were genotyped. No significant associations were found between circulating endothelin levels and EDV or FMD. No single genotype was related to EDV or FMD following adjustment for multiple testing, but a genotype score for 3 SNPs (rs11618266 in [[EDNRB]], rs17675063 in [[EDNRA]], rs3026868 in ECE1) was significantly related to EDV (beta coefficient 0.070, 95% CI 0.025-0.12, P = 0.002) when adjusting for gender, systolic blood pressure, HDL and LDL cholesterol, serum triglycerides, BMI, diabetes, smoking, antihypertensive medication or statins and [[CRP]]. This score was also related to nitroprusside-induced vasodilation in the forearm. A combination of genotypes in the endothelin pathway was related to both endothelium-dependent and endothelium-independent vasodilation in forearm resistance vessels, but not in the brachial artery in an elderly population, giving evidence for a role of the endothelin system in resistance vessel reactivity independent of major cardiovascular risk factors.
|mesh-terms=* Age Factors
* Aged
* Aging
* Aspartic Acid Endopeptidases
* Brachial Artery
* Endothelin-1
* Endothelin-Converting Enzymes
* Endothelium, Vascular
* Female
* Forearm
* Genotype
* Humans
* Infusions, Intra-Arterial
* Linear Models
* Male
* Metalloendopeptidases
* Phenotype
* Polymorphism, Single Nucleotide
* Prospective Studies
* Receptor, Endothelin A
* Receptor, Endothelin B
* Regional Blood Flow
* Sweden
* Ultrasonography
* Vasodilation
* Vasodilator Agents

|full-text-url=https://sci-hub.do/10.1111/apha.12068
}}