Редактирование: DUSP4 (раздел)

==Publications==

{{medline-entry
|title=Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22434910
|abstract=T cell-dependent B-cell responses decline with age, suggesting defective [[CD4]] T-cell function. [[CD4]] memory T cells from individuals older than 65 y displayed increased and sustained transcription of the dual-specific phosphatase 4 ([[DUSP4]]) that shortened expression of [[CD4]]0-ligand ([[CD4]]0L) and inducible T-cell costimulator ([[ICOS]]) (both P < 0.001) and decreased production of IL-4, IL-17A, and IL-21 (all P < 0.001) after in vitro activation. In vivo after influenza vaccination, activated [[CD4]] T cells from elderly individuals had increased [[DUSP4]] transcription (P = 0.002), which inversely correlated with the expression of [[CD4]]0L (r = 0.65, P = 0.002), [[ICOS]] (r = 0.57, P = 0.008), and IL-4 (r = 0.66, P = 0.001). In [[CD4]] KO mice reconstituted with [[DUSP4]] OT-II T cells, [[DUSP4]] had a negative effect on the expansion of antigen-specific B cells (P = 0.003) and the production of ova-specific antibodies (P = 0.03) after immunization. Silencing of [[DUSP4]] in memory [[CD4]] T cells improved [[CD4]]0L (P < 0.001), IL-4 (P = 0.007), and IL-21 (P = 0.04) expression significantly more in the elderly than young adults. Consequently, the ability of [[CD4]] memory T cells to support B-cell differentiation that was impaired in the elderly (P = 0.004) was restored. Our data suggest that increased [[DUSP4]] expression in activated T cells in the elderly in part accounts for defective adaptive immune responses.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Animals
* B-Lymphocytes
* Biomarkers
* CD4-Positive T-Lymphocytes
* Dual-Specificity Phosphatases
* Gene Silencing
* Humans
* Immunity, Humoral
* Immunologic Memory
* Influenza, Human
* Lymphocyte Activation
* Mice
* Mitogen-Activated Protein Kinase Phosphatases
* Protein Tyrosine Phosphatases
* Signal Transduction
* T-Lymphocytes, Helper-Inducer
* Vaccination
* Young Adult

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3326453
}}