Редактирование: DOC2A (раздел)

==Publications==

{{medline-entry
|title=Different spatiotemporal expression of DOC2 genes in the developing rat brain argues for an additional, nonsynaptic role of [[DOC2B]] in early development.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10651871
|abstract=[[DOC2A]] and [[DOC2B]] are two homologous genes implicated in synaptic vesicle exocytosis. Their complementary, nonoverlapping expression patterns in adult rat brain suggest that they exert similar functions in different neurons. We have analysed the expression pattern of the two genes in the developing rat brain by in situ hybridization. Unexpectedly, we found no parallel expression of the two genes during development. [[DOC2B]] mRNA was highly expressed as early as embryonic day 12 (E12) throughout the neuroepithelium, long before synaptic transmission is functional, and the expression remained abundant from E12 onwards. In contrast, faint expression of [[DOC2A]] transcripts was first detected at E17 in ventral brain areas, and it extended gradually to other brain structures in the sequence of their ontology, i.e. structures that had formed first also expressed [[DOC2A]] first. At postnatal day 3, both genes were highly expressed throughout the brain. This overlapping expression diverged to the complementary distribution of the adult brain. The temporal and spatial differences in expression point to a functional divergence between these homologous genes during brain development: the pattern of [[DOC2A]] is consistent with its proposed synaptic function, whereas that of [[DOC2B]] suggests an additional, nonsynaptic role in proliferating cells.
|mesh-terms=* Aging
* Animals
* Brain
* Calcium-Binding Proteins
* Embryonic and Fetal Development
* Female
* Gene Expression Regulation, Developmental
* Hippocampus
* In Situ Hybridization
* Male
* Neocortex
* Nerve Tissue Proteins
* Organ Specificity
* Protein Isoforms
* RNA, Messenger
* Rats
* Rats, Wistar
* Transcription, Genetic

|full-text-url=https://sci-hub.do/10.1046/j.1460-9568.2000.00898.x
}}