Редактирование: DMC1 (раздел)

==Publications==

{{medline-entry
|title=Early meiotic-specific protein expression in post-natal rat ovaries.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20345585
|abstract=Recent studies in mice challenged the basic doctrine that most mammalian females lose neo-oogenesis in post-natal ovaries. In order to provide more information in other species, we examined post-natal rat ovaries by histological sections and detected the germline cell marker protein RVLG (rat vasa-like gene), BrdU (5-bromodeoxyuridine) incorporation in RVLG-expressing cells, for identification of germline cells undergoing mitosis and meiosis in the ovarian surface epithelium (OSE). We also detected the expression of early meiotic-specific proteins disruption of meiotic control 1 ([[DMC1]]), stimulated by retinoic acid gene 8 ([[STRA8]]) and synaptonemal complex protein 3 (SCP3) by immunohistochemical analysis and Western blotting, and the transcript of SCP1, SCP3 and Sporulation-specific protein 11 ([[SPO11]]) by RT-PCR in the post-natal ovarian cortex. However we failed in detecting large ovoid cells in the OSE, which may represent the putative germline stem cells (GSCs) that are supposed to sustain neo-oogenesis, and the transcription of the meiotic-specific genes SCP1, SCP3 and [[SPO11]] by RT-PCR as well as the translation of [[DMC1]], [[STRA8]] and SCP3 by Western blotting. Our data support the postulation that there is no neo-oogenesis occurring in the OSE of rat post-natal ovary through meiosis of GSCs.
|mesh-terms=* Aging
* Animals
* Blotting, Western
* Female
* Gene Expression Profiling
* Gene Expression Regulation
* Male
* Meiosis
* Ovary
* Rats
* Rats, Wistar

|full-text-url=https://sci-hub.do/10.1111/j.1439-0531.2010.01599.x
}}