Редактирование: DLST (раздел)

==Publications==

{{medline-entry
|title=Comparative study of the usefulness of the drug-induced lymphocyte stimulation test and the leukocyte migration test in drug allergies.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/18239291
|abstract=In 133 patients suspected of hypersensitivity to drugs and 102 control patients without hypersensitivity to drugs, the identification of allergenic drugs was performed by the drug-induced lymphocyte stimulation test ([[DLST]]) and the leukocyte migration test (LMT) to compare their usefulness in identifying drug allergies. In the 133 subject patients, the positive rate was 24.8% on the [[DLST]] and 60.9% on the LMT (agreement rate; 77.4%); thus, the LMT showed a significantly higher positive rate than the [[DLST]] (p<0.000001, chi(2)-test). In the 102 control patients, the positive rates on the [[DLST]] and LMT were 6.9%. In addition, the LMT showed a higher positive rate than the [[DLST]] for many hypersensitivity symptoms such as skin eruptions and hepatic injury, and for many drug efficacy categories of the suspected drugs such as antibacterial drugs, etc. Furthermore, the positive rate of the [[DLST]] did not change when adjusted for the patients' serum and sex, while that of the LMT increased when adjusted for the patients' serum and was found to be higher in females than in males. Our findings indicate that the LMT may be more useful than the [[DLST]] in identifying the causative drug in drug allergies and that its interpretation is influenced by the patient's serum and sex.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Aging
* Antibody Specificity
* Antigens
* Cell Migration Assays, Leukocyte
* Cell Separation
* Child
* Child, Preschool
* Drug Hypersensitivity
* Female
* Humans
* Infant
* Lymphocyte Activation
* Male
* Middle Aged
* Monocytes
* Predictive Value of Tests
* Sex Characteristics

|full-text-url=https://sci-hub.do/10.1248/bpb.31.299
}}
{{medline-entry
|title=Distribution of geriatric disease-related genotypes in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA).
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/10835828
|abstract=Phenotypes of various genes related to geriatric diseases and the aging process were assessed in the National Institute for Longevity Sciences, Longitudinal Study of Aging (NILS-LSA). The subjects were 1,297 participants in the NILS-LSA. They were community-living males and females aged 40 to 79 years who were randomly selected from the area of the NILS. Genotypic and allelic frequencies of genes in the subjects were analyzed. Age and gender differences in the distribution of genotypes were also tested. The genotypic frequencies were as follows: (1) Angiotensin I-converting enzyme ([[ACE]]) genotype was I/I 46.2%, I/D 38.3% and D/D 15.5%. (2) alpha 1-adrenoreceptor genotype was C/C 84.4%, C/T 12.7%, and T/T 3.0%. (3) Apolipoprotein E genotype was epsilon 2/epsilon 2 0%, epsilon 2/epsilon 3 7.9%, epsilon 3/epsilon 3 70.0%, epsilon 3/epsilon 4 20.8%, epsilon 2/epsilon 4 0%, and epsilon 4/epsilon 4 1.4%. (4) Cholecystokinin type-A receptor ([[CCKAR]]) nucleotide-81 (nt-81) genotype was A/A 59.1%, A/G 35.1%, and G/G 5.9%. The [[CCKAR]] nucleotide-128 genotype (nt-128) was G/G 74.3%, G/T 23.6%, and T/T 2.2%. The combination of nucleotide (nt-81, nt-128) was (A/A, G/G) 59.1%, (A/G, G/G) 14.1%, (G/G, G/G) 1.1%, (A/G, G/T) 21.0%, (G/G, G/T) 2.6%, and (G/G, T/T) 2.1%. There were no subjects with (A/A, G/T), (A/A, T/T) or (A/G, T/T) genotypic combinations. (5) beta 3-adrenoreceptor genotype was T/T 66.8%, T/A 28.5%, and A/A 4.7%. (6) Dihydrolipoamide succinyltransferase ([[DLST]]) nucleotide 19117 genotype was A/A 25.1%, A/G 49.7%, and G/G 25.1%. The [[DLST]] nucleotide 19183 genotype was C/C 55.8%, C/T 38.2%, and T/T 5.9%. The combination of nucleotide (nt19117, nt19183) was (A/A, C/C) 6.7%, (A/G, C/C) 24.1%, (G/G, C/C) 25.1%, (A/G, C/T) 25.6%, (A/A, T/T) 5.9%, and (A/A, C/T) 12.6%. There were no subjects with (A/G, T/T), (G/G, T/T) or (G/G, T/C) genotypic combinations. (7) Transforming growth factor-beta 1 genotype T/T 35.2%, T/C 44.6%, and C/C 20.2%. (8) The platelet-activating factor acetylhydrolase genotype was M/M 71.7%, M/m 27.2%, and m/m 1.2%. The mitochondria DNA 5178 genotype A was 42.1% and C was 57.9%. There were no significant gender or age differences in tested genotypic and allelic distribution except for the [[DLST]] and apolipoprotein E. Differences in the genotypic frequencies of distribution using the Hardy-Weinberg equilibrium were significant in the [[ACE]] and alpha 1-adrenoreceptor genotypes.
|mesh-terms=* Adult
* Age Distribution
* Aged
* Aging
* Alleles
* Apolipoproteins E
* Female
* Genotype
* Geriatric Assessment
* Geriatrics
* Humans
* Japan
* Longitudinal Studies
* Male
* Middle Aged
* Molecular Epidemiology
* Peptidyl-Dipeptidase A
* Receptors, Purinergic P1
* Sex Distribution

|full-text-url=https://sci-hub.do/10.2188/jea.10.1sup_46
}}