Редактирование: DDX41 (раздел)

==Publications==

{{medline-entry
|title=Salidroside influences the cellular cross-talk of human fetal lung diploid fibroblasts: A proteomic approach.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29329019
|abstract=Senescence is a complex multiple factor proces, which is still poorly understood. The purpose of this study was to find the proteome of cultured human fetal lung diploid fibroblasts (2BS) of different population doubling (PD), as well as the altered proteome induced by salidroside (SAL) in 2BS cells. Proteins were identified by two-dimensional electrophoresis (2-DE) combining matrix-assisted laser desorption/ionization-time and flight mass spectrometry (MAL DI-TOF/MS). As a result, we found 16 proteins with two-fold variations in senescent cells or after SAL treatment, some being reduced such as reticulocalbin-1, heat shock protein beta-6, elongation factor 1-delta, F-actin-capping protein subunit alpha-1, and chloride intracellular channel 1. In contrast, 40S ribosomal protein SA, proteasome subunit alpha type-5, and zinc finger BED domain-containing protein 5 increased with cell age. Furthermore, heat shock protein beta-6, Zinc finger BED domain-containing protein 5 was increased in PD30 cells after 10 μM SAL treatment, whereas, elongation factor 1-delta, 6-phosphogluconolactonase, Nucleoside diphosphate kinase A, F-actin-capping protein subunit alpha-1, Probable ATP-dependent RNA helicase [[DDX41]], Chloride intracellular channel 1, and Peroxiredoxin-6 were increased in PD50 cells after 10 μM SAL treatment. Some of these proteins were involved in the protein synthetic and degradative pathways, which emphasizes the metabolic disorder or functional impairment of cell senescence. Moreover, these proteins could be candidate biomarkers for evaluating the SAL anti-senescence effect.
|mesh-terms=* Cell Line
* Cellular Senescence
* Diploidy
* Fetus
* Fibroblasts
* Glucosides
* Humans
* Lung
* Phenols
* Proteome
* Proteomics
|keywords=* Human fetal lung diploid fibroblast cell
* Proteomics
* Salidroside
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.etap.2018.01.001
}}
{{medline-entry
|title=Sequential acquisition of mutations in myelodysplastic syndromes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28978821
|abstract=Recent progress in next-generation sequencing technologies allows us to discover frequent mutations throughout the coding regions of myelodysplastic syndromes (MDS), potentially providing us with virtually a complete spectrum of driver mutations in this disease. As shown by many study groups these days, such driver mutations are acquired in a gene-specific fashion. For instance, [[DDX41]] mutations are observed in germline cells long before MDS presentation. In blood samples from healthy elderly individuals, somatic [[DNMT3A]] and [[TET2]] mutations are detected as age-related clonal hematopoiesis and are believed to be a risk factor for hematological neoplasms. In MDS, mutations of genes such as [[NRAS]] and [[FLT3]], designated as Type-1 genes, may be significantly associated with leukemic evolution. Another type (Type-2) of genes, including [[RUNX1]] and [[GATA2]], are related to progression from low-risk to high-risk MDS. Overall, various driver mutations are sequentially acquired in MDS, at a specific time, in either germline cells, normal hematopoietic cells, or clonal MDS cells.
|mesh-terms=* Aging
* DEAD-box RNA Helicases
* Genome, Human
* Humans
* Mutation
* Myelodysplastic Syndromes
* Prognosis
|keywords=* Germline mutations
* Myelodysplastic syndromes
* Secondary acute myeloid leukemia
* Somatic mutations
|full-text-url=https://sci-hub.do/10.11406/rinketsu.58.1828
}}