Редактирование: DCXR (раздел)

==Publications==

{{medline-entry
|title=Dicarbonyl/l-xylulose reductase ([[DCXR]]): The multifunctional pentosuria enzyme.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23988570
|abstract=Dicarbonyl/L-xylulose reductase ([[DCXR]]) is a highly conserved and phylogenetically widespread enzyme converting L-xylulose into xylitol. It also reduces highly reactive α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. Enzymatic properties of [[DCXR]] from yeast, fungi and mammalian tissue extracts are extensively studied. Deficiency of the [[DCXR]] gene causes a human clinical condition called pentosuria and low [[DCXR]] activity is implicated in age-related diseases including cancers, diabetes, and human male infertility. While mice provide a model to study clinical condition of these diseases, it is necessary to adopt a physiologically tractable model in which genetic manipulations can be readily achieved to allow the fast genetic analysis of an enzyme with multiple biological roles. Caenorhabditis elegans has been successfully utilized as a model to study [[DCXR]]. Here, we discuss the biochemical properties and significance of [[DCXR]] activity in various human diseases, and the utility of C. elegans as a research platform to investigate the molecular and cellular mechanism of the [[DCXR]] biology.
|mesh-terms=* Amino Acid Sequence
* Animals
* Carbohydrate Metabolism, Inborn Errors
* Humans
* Models, Molecular
* Molecular Sequence Data
* Sugar Alcohol Dehydrogenases
* Xylulose
|keywords=* AGE
* DC
* DCXR
* DEP
* Dicarbonyl/l-xylulose dehydrogenase
* Fertility
* Longevity
* Pentosuria
* RAGE
* SDR
* advanced glycation end-products
* dhs-21
* dicarbonyl/l-xylulose reductase
* diesel exhaust particles
* receptor for AGE
* short-chain dehydrogenase/reductase
* α-dicarbonyl compound
|full-text-url=https://sci-hub.do/10.1016/j.biocel.2013.08.010
}}
{{medline-entry
|title=DHS-21, a dicarbonyl/L-xylulose reductase ([[DCXR]]) ortholog, regulates longevity and reproduction in Caenorhabditis elegans.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/21477590
|abstract=Dicarbonyl/L-xylulose reductase ([[DCXR]]) converts l-xylulose into xylitol, and reduces various α-dicarbonyl compounds, thus performing a dual role in carbohydrate metabolism and detoxification. In this study, we identified DHS-21 as the only [[DCXR]] ortholog in Caenorhabditis elegans. The dhs-21 gene is expressed in various tissues including the intestine, gonadal sheath cells, uterine seam (utse) cells, the spermathecal-uterus (sp-ut) valve and on the plasma membrane of spermatids. Recombinant DHS-21 was shown to convert L-xylulose to xylitol using NADPH as a cofactor. Dhs-21 null mutants of C. elegans show defects in longevity, reproduction and egg-laying. Knock-down of daf-16 and elt-2 transcription factors affected dhs-21 expression. These results suggest that DHS-21 is a bona fide [[DCXR]] of C. elegans, essential for normal life span and reproduction.
|mesh-terms=* Amino Acid Sequence
* Animals
* Animals, Genetically Modified
* Biocatalysis
* Blotting, Western
* Caenorhabditis elegans
* Caenorhabditis elegans Proteins
* Female
* Green Fluorescent Proteins
* Kinetics
* Longevity
* Male
* Microscopy, Fluorescence
* Molecular Sequence Data
* Mutation
* NADP
* RNA Interference
* Recombinant Proteins
* Reproduction
* Sequence Homology, Amino Acid
* Sugar Alcohol Dehydrogenases
* Xylitol
* Xylulose

|full-text-url=https://sci-hub.do/10.1016/j.febslet.2011.03.062
}}