Редактирование: DCTN1 (раздел)

==Publications==

{{medline-entry
|title=Alteration of Motor Protein Expression Involved in Bidirectional Transport in Peripheral Blood Mononuclear Cells of Patients with Amyotrophic Lateral Sclerosis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26954557
|abstract=Sporadic amyotrophic lateral sclerosis (SALS) is a fatal motor neuron degenerative disease of unclear pathogenesis. Disturbances of intracellular transport are possible causes of the disease. We evaluated the expression of motor proteins involved in the anterograde (kinesins [[KIF1B]], [[KIF5C]]) and retrograde ([[KIFC3]], dynactin subunits [[DCTN1]] and [[DCTN3]]) intracellular transport in peripheral blood mononuclear cells (PBMCs). PBMCs were obtained from 74 SALS patients with different clinical phenotypes, 65 blood donors (healthy control I), and 29 cases with other neurological diseases (disease control II) divided into subgroups IIA (atypical parkinsonism) and IIB (ALS-mimicking disorders). mRNA expression was studied by real-time qPCR, and protein level by Western blotting. In SALS, [[KIF5C]] and [[KIFC3]] expression was significantly lower and [[DCTN1]] higher than in control I, and dependent of age. [[KIF1B]] expression was significantly higher in SALS than in subgroup IIB, whereas [[DCTN1]] and [[DCTN3]] were higher in SALS than in subgroup IIA. All changes in the studied proteins were statistically significant in classic ALS but not in progressive muscular atrophy. In SALS, and especially in classic ALS, the changes in motor protein expression may alter bidirectional intracellular transport in PBMCs. More studies are needed to find out whether the levels of [[KIF5C]] and [[DCTN1]] may be useful in ALS diagnosis, and whether [[KIF1B]] expression may discriminate ALS from ALS-mimicking disorders.
|mesh-terms=* Adult
* Aged
* Aged, 80 and over
* Aging
* Amyotrophic Lateral Sclerosis
* Biomarkers
* Blotting, Western
* Dynactin Complex
* Female
* Humans
* Kinesin
* Leukocytes, Mononuclear
* Male
* Middle Aged
* RNA, Messenger
* Real-Time Polymerase Chain Reaction
* Young Adult

|full-text-url=https://sci-hub.do/10.1159/000443664
}}