Редактирование: CYP4X1 (раздел)

==Publications==

{{medline-entry
|title=Sex- and age-dependent gene expression in human liver: An implication for drug-metabolizing enzymes.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28153492
|abstract=Sex and age differences in hepatic expression of drug-metabolizing enzyme genes could cause variations in drug metabolism, but has not been fully elucidated, especially in Asian population. In this study, the global expression of human hepatic genes was analyzed by microarrays in 40 Japanese subjects (27 males and 13 females). Thirty-five sex-biased genes were identified (P < 0.005). Whereas, 60 age-biased genes in two age groups, <60 years and ≥70 years (P < 0.001), were identified in males. By Gene Ontology analysis, the sex-biased genes were related to protein catabolism and modification, while the age-biased genes were related to transcription regulation and cell death. Quantitative polymerase chain reaction confirmed the female-biased expression of drug-metabolizing enzyme genes BChE, [[CYP4X1]], and [[SULT1E1]] (≥1.5-fold, P < 0.05). Further analysis of drug-metabolizing enzyme genes indicated that expression of [[CYP2A6]] and [[CYP3A4]] in females in the ≥70 age group was less than in the <60 age group (≥1.5-fold, P < 0.05), and this trend was also observed for PXR expression in males (≥1.5-fold, P < 0.05). The results presented provide important insights into hepatic physiology and function, especially drug metabolism, with respect to sex and age.
|mesh-terms=* Aged
* Aging
* Butyrylcholinesterase
* Cytochrome P-450 Enzyme System
* Female
* Gene Expression Profiling
* Gene Expression Regulation, Enzymologic
* Humans
* Liver
* Male
* Middle Aged
* Oligonucleotide Array Sequence Analysis
* Pharmaceutical Preparations
* Pregnane X Receptor
* Receptors, Steroid
* Sex Characteristics
* Sulfotransferases
|keywords=* Age
* Cytochrome P450
* Drug metabolism
* Gene expression
* Liver
* Sex
|full-text-url=https://sci-hub.do/10.1016/j.dmpk.2016.10.409
}}