Редактирование: CYFIP2 (раздел)

==Publications==

{{medline-entry
|title=Age-related gene-specific changes of A-to-I mRNA editing in the human brain.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20538013
|abstract=A-to-I editing is an adenosine-to-inosine modification of mRNA particularly widespread in the human brain, where it affects thousands of genes. A growing body of evidence suggests that A-to-I RNA editing is necessary for normal development and maintenance in mammals and that its deficiencies contribute to a number of pathological states. In this study, we examined whether mRNA editing levels of two mRNA species, [[CYFIP2]] and [[GABRA3]], change with aging. [[CYFIP2]] has been implicated in synaptic maintenance, while [[GABRA3]] is a GABA receptor subunit, a part of the major inhibitory neurotransmitter system in the CNS. The levels of mRNA editing were assessed in cortex samples of 20 subjects 22-102 years old. The data show an age-dependent statistically significant decrease in editing in [[CYFIP2]]. [[GABRA3]] editing remained much more stable with age, implying that age-related decline of RNA editing is gene-specific. This is the first report of age-dependent decline in A-to-I editing. Further examination of these and other vulnerable genes may reveal specific RNA editing mechanisms that contribute to the aging phenotype.
|mesh-terms=* Adaptor Proteins, Signal Transducing
* Adenosine
* Adult
* Aged
* Aged, 80 and over
* Aging
* Cerebral Cortex
* Female
* Humans
* Inosine
* Male
* Middle Aged
* RNA Editing
* Receptors, GABA-A
* Young Adult

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2915444
}}