Редактирование: CTSC (раздел)

==Publications==

{{medline-entry
|title=Frontotemporal dementia: insights into the biological underpinnings of disease through gene co-expression network analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26912063
|abstract=In frontotemporal dementia (FTD) there is a critical lack in the understanding of biological and molecular mechanisms involved in disease pathogenesis. The heterogeneous genetic features associated with FTD suggest that multiple disease-mechanisms are likely to contribute to the development of this neurodegenerative condition. We here present a systems biology approach with the scope of i) shedding light on the biological processes potentially implicated in the pathogenesis of FTD and ii) identifying novel potential risk factors for FTD. We performed a gene co-expression network analysis of microarray expression data from 101 individuals without neurodegenerative diseases to explore regional-specific co-expression patterns in the frontal and temporal cortices for 12 genes ([[MAPT]], [[GRN]], [[CHMP2B]], [[CTSC]], [[HLA-DRA]], [[TMEM106B]], [[C9orf72]], [[VCP]], [[UBQLN2]], [[OPTN]], [[TARDBP]] and FUS) associated with FTD and we then carried out gene set enrichment and pathway analyses, and investigated known protein-protein interactors (PPIs) of FTD-genes products. Gene co-expression networks revealed that several FTD-genes (such as [[MAPT]] and [[GRN]], [[CTSC]] and [[HLA-DRA]], [[TMEM106B]], and [[C9orf72]], [[VCP]], [[UBQLN2]] and [[OPTN]]) were clustering in modules of relevance in the frontal and temporal cortices. Functional annotation and pathway analyses of such modules indicated enrichment for: i) DNA metabolism, i.e. transcription regulation, DNA protection and chromatin remodelling ([[MAPT]] and [[GRN]] modules); ii) immune and lysosomal processes ([[CTSC]] and [[HLA-DRA]] modules), and; iii) protein meta/catabolism ([[C9orf72]], [[VCP]], [[UBQLN2]] and [[OPTN]], and [[TMEM106B]] modules). PPI analysis supported the results of the functional annotation and pathway analyses. This work further characterizes known FTD-genes and elaborates on their biological relevance to disease: not only do we indicate likely impacted regional-specific biological processes driven by FTD-genes containing modules, but also do we suggest novel potential risk factors among the FTD-genes interactors as targets for further mechanistic characterization in hypothesis driven cell biology work.
|mesh-terms=* Aging
* Animals
* Brain Mapping
* Frontotemporal Dementia
* Gene Regulatory Networks
* Genetic Predisposition to Disease
* Intercellular Signaling Peptides and Proteins
* Mutation
* Risk Factors
* tau Proteins

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4765225
}}
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