Редактирование: CLCN6 (раздел)

==Publications==

{{medline-entry
|title=DNA methylation levels at individual age-associated CpG sites can be indicative for life expectancy.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26928272
|abstract=DNA-methylation (DNAm) levels at age-associated CpG sites can be combined into epigenetic aging signatures to estimate donor age. It has been demonstrated that the difference between such epigenetic age-predictions and chronological age is indicative for of all-cause mortality in later life. In this study, we tested alternative epigenetic signatures and followed the hypothesis that even individual age-associated CpG sites might be indicative for life-expectancy. Using a 99-CpG aging model, a five-year higher age-prediction was associated with 11% greater mortality risk in DNAm profiles of the Lothian Birth Cohort 1921 study. However, models based on three CpGs, or even individual CpGs, generally revealed very high offsets in age-predictions if applied to independent microarray datasets. On the other hand, we demonstrate that DNAm levels at several individual age-associated CpGs seem to be associated with life expectancy - e.g., at CpGs associated with the genesPDE4C and [[CLCN6]]. Our results support the notion that small aging signatures should rather be analysed by more quantitative methods, such as site-specific pyrosequencing, as the precision of age-predictions is rather low on independent microarray datasets. Nevertheless, the results hold the perspective that simple epigenetic biomarkers, based on few or individual age-associated CpGs, could assist the estimation of biological age. 
|mesh-terms=* Aged
* Aging
* CpG Islands
* DNA Methylation
* Epigenesis, Genetic
* Female
* Humans
* Life Expectancy
* Male
* Proportional Hazards Models
|keywords=* CLCN6
* DNA-methylation
* PDE4C
* age
* aging
* epigenetic
* mortality
* prediction
* predictor
* survival
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4789590
}}