Редактирование: CIAO1 (раздел)

==Publications==

{{medline-entry
|title=Inhibited [[PTHLH]] downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network in no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) by systems-theoretical analysis.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/22955522
|abstract=We analyzed the different biological processes and occurrence numbers between low expression inhibited [[PTHLH]] downstream-mediated aging gene ontology (GO) network of no-tumor hepatitis/cirrhotic tissues (HBV or HCV infection) and the corresponding high expression (fold change ≥2) inhibited GO network of human hepatocellular carcinoma (HCC). Inhibited [[PTHLH]] downstream-mediated aging network consisted of aging, branched chain family amino acid biosynthesis, cellular metabolism, cholesterol biosynthesis, coupled to cyclic nucleotide second messenger, cytolysis, 'de novo' GDP-l-fucose biosynthesis, detection of mechanical stimulus, glucose homeostasis, G-protein signaling, leukocyte adhesion, iron-sulfur cluster assembly, JAK-STAT cascade, Notch signaling pathway, nucleotide-sugar metabolism, peptidyl-tyrosine sulfation, protein amino acid N-linked glycosylation, protein amino acid phosphorylation, response to drug, rRNA processing, translational initiation, ubiquitin-dependent protein catabolism, homophilic cell adhesion in no-tumor hepatitis/cirrhotic tissues. We proposed inhibited [[PTHLH]] downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network. Our hypothesis was verified by the same inhibited [[PTHLH]] downstream-mediated aging GO network in no-tumor hepatitis/cirrhotic tissues with the corresponding activated GO network of HCC, or the different with the corresponding activated GO network of no-tumor hepatitis/cirrhotic tissues. Inhibited [[PTHLH]] downstream leukocyte adhesion-mediated protein amino acid N-linked glycosylation coupling Notch and JAK-STAT cascade to iron-sulfur cluster assembly-induced aging network included TSTA3, [[ALK]], [[CIAO1]], [[NOTCH3]] in no-tumor hepatitis/cirrhotic tissues from the GEO data set using gene regulatory network inference method and our programming.
|mesh-terms=* Aging
* Fibrosis
* Gene Expression Regulation, Neoplastic
* Glycosylation
* Hepacivirus
* Hepatitis
* Hepatitis B virus
* Homeostasis
* Humans
* Iron-Sulfur Proteins
* Leukocytes
* Models, Biological
* Neoplasms
* Oligonucleotide Array Sequence Analysis
* Parathyroid Hormone-Related Protein
* Phosphorylation
* Receptors, Notch
* Signal Transduction
* Systems Theory

|full-text-url=https://sci-hub.do/10.1039/c2ib20148h
}}