Редактирование: CELSR2 (раздел)

==Publications==

{{medline-entry
|title=Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27329260
|abstract=The growth hormone/insulin-like growth factor (IGF) axis can be manipulated in animal models to promote longevity, and IGF-related proteins including IGF-I and IGF-binding protein-3 (IGFBP-3) have also been implicated in risk of human diseases including cardiovascular diseases, diabetes, and cancer. Through genomewide association study of up to 30 884 adults of European ancestry from 21 studies, we confirmed and extended the list of previously identified loci associated with circulating IGF-I and IGFBP-3 concentrations (IGF1, [[IGFBP3]], [[GCKR]], [[TNS3]], [[GHSR]], [[FOXO3]], [[ASXL2]], [[NUBP2]]/IGFALS, [[SORCS2]], and [[CELSR2]]). Significant sex interactions, which were characterized by different genotype-phenotype associations between men and women, were found only for associations of IGFBP-3 concentrations with SNPs at the loci [[IGFBP3]] and [[SORCS2]]. Analyses of SNPs, gene expression, and protein levels suggested that interplay between [[IGFBP3]] and genes within the [[NUBP2]] locus (IGFALS and HAGH) may affect circulating IGF-I and IGFBP-3 concentrations. The IGF-I-decreasing allele of SNP rs934073, which is an eQTL of [[ASXL2]], was associated with lower adiposity and higher likelihood of survival beyond 90 years. The known longevity-associated variant rs2153960 ([[FOXO3]]) was observed to be a genomewide significant SNP for IGF-I concentrations. Bioinformatics analysis suggested enrichment of putative regulatory elements among these IGF-I- and IGFBP-3-associated loci, particularly of rs646776 at [[CELSR2]]. In conclusion, this study identified several loci associated with circulating IGF-I and IGFBP-3 concentrations and provides clues to the potential role of the IGF axis in mediating effects of known ([[FOXO3]]) and novel ([[ASXL2]]) longevity-associated loci. 
|mesh-terms=* Adult
* Aging
* Female
* Gene Expression Regulation
* Genome-Wide Association Study
* Humans
* Insulin-Like Growth Factor Binding Protein 3
* Insulin-Like Growth Factor I
* Male
* Metabolome
* Quantitative Trait Loci
* Quantitative Trait, Heritable
* Regulatory Sequences, Nucleic Acid
|keywords=* IGF-I
* IGFBP-3
* aging
* genomewide association study
* growth hormone axis
* longevity
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013013
}}