Редактирование: CDCA3 (раздел)

==Publications==

{{medline-entry
|title=Expression of [[CDCA3]] Is a Prognostic Biomarker and Potential Therapeutic Target in Non-Small Cell Lung Cancer.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28487093
|abstract=NSCLC is the leading cause for cancer-related deaths worldwide. New therapeutic targets are needed, as development of resistance to current treatment, such as platinum-based chemotherapy, is inevitable. The purpose of this study was to determine the functional relevance and therapeutic potential of cell division cycle associated 3 protein ([[CDCA3]]) in NSCLC. The expression of [[CDCA3]] in squamous and nonsquamous NSCLC was investigated by using bioinformatics, Western blot analysis of matched tumor and normal tissue, and immunohistochemistry of a tissue microarray. The function of [[CDCA3]] in NSCLC was determined by using several in vitro assays with small interfering RNA depleting [[CDCA3]] in a panel of three immortalized human bronchial epithelial cell (HBEC) lines and seven NSCLC cell lines. In this study, cell division cycle associated 3 gene ([[CDCA3]]) transcripts were identified as highly increased in NSCLC versus in nonmalignant tissue, with high levels of [[CDCA3]] being associated with poor patient prognosis. [[CDCA3]] protein was also increased in NSCLC tissue and expression was limited to tumor cells. [[CDCA3]] expression was similarly increased in a panel of NSCLC cell lines compared with in three HBEC lines. Although depletion of [[CDCA3]] in the HBEC lines did not affect cellular proliferation, depletion of [[CDCA3]] expression markedly reduced the proliferation of all NSCLC cell lines. [[CDCA3]] depletion caused a defective G2/M-phase cell cycle progression, upregulation of p21 independent of p53, and induction of cellular senescence. Our findings highlight [[CDCA3]] as a prognostic factor and potential novel therapeutic target in NSCLC through inhibition of tumor growth and promotion of tumor senescence.
|mesh-terms=* Aged
* Carcinoma, Non-Small-Cell Lung
* Cell Cycle Proteins
* Humans
* Lung Neoplasms
* Prognosis
* Transfection
|keywords=* CDCA3
* Cell cycle
* Non–small cell lung cancer
* Prognostic biomarker
* Senescence
|full-text-url=https://sci-hub.do/10.1016/j.jtho.2017.04.018
}}