Редактирование: CBR1 (раздел)

==Publications==

{{medline-entry
|title=Age-related changes in hepatic activity and expression of detoxification enzymes in male rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/23971034
|abstract=Process of aging is accompanied by changes in the biotransformation of xenobiotics and impairment of normal cellular functions by free radicals. Therefore, this study was designed to determine age-related differences in the activities and/or expressions of selected drug-metabolizing and antioxidant enzymes in young and old rats. Specific activities of 8 drug-metabolizing enzymes and 4 antioxidant enzymes were assessed in hepatic subcellular fractions of 6-week-old and 21-month-old male Wistar rats. Protein expressions of carbonyl reductase 1 ([[CBR1]]) and glutathione S-transferase (GST) were determined using immunoblotting. Remarkable age-related decrease in specific activities of CYP2B, CYP3A, and UDP-glucuronosyl transferase was observed, whereas no changes in activities of [[CYP1A2]], flavine monooxygenase, aldo-keto reductase 1C, and antioxidant enzymes with advancing age were found. On the other hand, specific activity of [[CBR1]] and GST was 2.4 folds and 5.6 folds higher in the senescent rats compared with the young ones, respectively. Interindividual variability in [[CBR1]] activity increased significantly with rising age. We suppose that elevated activities of GST and [[CBR1]] may protect senescent rats against xenobiotic as well as eobiotic electrophiles and reactive carbonyls, but they may alter metabolism of drugs, which are [[CBR1]] and especially GSTs substrates. 
|mesh-terms=* Aging
* Animals
* Antioxidants
* Enzyme Activation
* Inactivation, Metabolic
* Liver
* Male
* Metabolic Clearance Rate
* Oxidoreductases
* Pharmaceutical Preparations
* Rats
* Rats, Wistar
* Xenobiotics

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3736498
}}