Редактирование: CASP5 (раздел)

==Publications==

{{medline-entry
|title=Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26448778
|abstract=Chronic low-grade inflammation is considered a driver of many age-related disorders, including vascular diseases (inflammaging). Inhibition of autophagic capacity with ageing was postulated to generate a pro-inflammatory condition via activation of inflammasomes, a group of Interleukin-1 activating intracellular multi-protein complexes. We thus investigated gene expression of inflammasome components in PBMC of 77 vascular patients (age 22-82) in association with age. Linear regression of real-time qRT-PCR data revealed a significant positive association of gene expression of each of the inflammasome components with age (Pearson correlation coefficients: [[AIM2]]: r = 0.245; P = 0.032; [[NLRP3]]: r = 0.367; P = 0.001; ASC (PYCARD): r = 0.252; P = 0.027; [[CASP1]]: r = 0.296; P = 0.009; [[CASP5]]: r = 0.453; P = 0.00003; [[IL1B]]: r = 0.247; P = 0.030). No difference in gene expression of [[AIM2]], [[NLRP3]], ASC [[CASP1]], and [[CASP5]] was detected between PBMC of patients with advanced atherosclerosis and other vascular patients, whereas [[IL1B]] expression was increased in PBMC of the latter group (P = 0.0005). The findings reinforce the systemic pro-inflammatory phenotype reported in elderly by demonstrating an increased phase-1 activation of inflammasomes in PBMC of vascular patients.

|keywords=* AIM2
* Aging
* Atherosclerosis
* Inflammation
* NLRP3
* Vascular disease
|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596365
}}
{{medline-entry
|title=Evidence for depletion of [[CASP5]] Ala90Thr heterozygous genotype in aged subjects.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/20434535
|abstract=Our previous studies, which included genotyping of multiple coding apoptotic gene polymorphisms, unexpectedly demonstrated a depletion of heterozygous [[CASP5]] Ala90Thr (rs507879, c.268 G>A) genotypes in elderly subjects. Present investigation was aimed to validate this trend. An analysis of 510 subjects aged 75-103years revealed 205 (40%) [[CASP5]] Ala90Thr heterozygotes as compared to 254 (50%) expected from the minor allele frequency 0.470 (p=0.000014). This deviation was not observed in 549 middle-aged (18-50years) controls (270 (49%) heterozygotes observed vs. 274 (50%) expected; minor allele frequency 0.475; p=0.743). Unfavorable significance of [[CASP5]] heterozygous genotype may be explained by the role of the caspase-5 in inflammation-related processes. Almost all prior gene-longevity association studies focused on discrimination between "good" and "bad" gene variants. Here we present a distinct situation, where the combination of alternative alleles (i.e., heterozygosity) appears to be unfavorable as compared to the homozygous carriership of either gene variant.
|mesh-terms=* Adolescent
* Adult
* Aged
* Aged, 80 and over
* Amino Acid Substitution
* Apoptosis
* Caspases
* DNA Primers
* Gene Frequency
* Genotype
* Heterozygote
* Homozygote
* Humans
* Longevity
* Lung Neoplasms
* Middle Aged
* Polymerase Chain Reaction
* Polymorphism, Genetic
* Smoking

|full-text-url=https://sci-hub.do/10.1016/j.exger.2010.04.007
}}