Редактирование: CACNA2D1 (раздел)

==Publications==

{{medline-entry
|title=Pregabalin can prevent, but not treat, cognitive dysfunction following abdominal surgery in aged rats.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26872983
|abstract=The present study aimed to explore the preventive or therapeutic effect of peri-operative pregabalin treatment on the memory deficits and related hippocampal inflammation following surgery in aged rats. Aged rats underwent abdominal or sham surgery, and were then divided into 2 groups, either early or late pregabalin treatment. Fourteen days after surgery, the cognitive function was assessed using novel object recognition test, followed by measurement of hippocampal cytokines and voltage-dependent calcium channel α2δ subunit ([[CACNA2D1]]). The parabiotic experiments determined whether the humoral or neuronal pathway was involved in the neuroinflammation development following the abdominal surgery. The effects of pregabalin on LPS-induced cytokine release from hippocampal microglia were also evaluated. Early pregabalin treatment, which was administered pre-operatively and continued for 3 or 7days after surgery, prevented memory deficits and decreased hippocampal pro-inflammatory cytokine levels. In contrast, no beneficial effects were observed when pregabalin was administered late in the post-operative period. The hippocampal levels of [[CACNA2D1]] did not change under any experimental condition. The data from the cross-circulation (parabiosis) experiments indicated that abdominal surgery may induce neuroinflammation via a neural transmission pathway from the periphery to the brain. The ex vivo experiments further demonstrated that pregabalin had no effect on LPS-induced cytokines release from hippocampal microglia. Our findings highlight reveal that peri-operative pregabalin treatment during the early post-operative period can prevent neuroinflammation and memory deficits after surgery. It is likely this occurs through a peripheral and central neuro-immune interaction rather than through direct anti-inflammatory effects.
|mesh-terms=* Abdominal Muscles
* Aging
* Animals
* Cognition Disorders
* Male
* Postoperative Complications
* Pregabalin
* Preoperative Care
* Rats
* Rats, Wistar
* Treatment Outcome
|keywords=* Microglia
* Neuroinflammation
* Post-operative cognitive dysfunction
|full-text-url=https://sci-hub.do/10.1016/j.lfs.2016.02.021
}}