Редактирование: C2CD2 (раздел)

==Publications==

{{medline-entry
|title=Genetic variants associated with physical performance and anthropometry in old age: a genome-wide association study in the ilSIRENTE cohort.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29158487
|abstract=Unraveling the complexity of aging is crucial for understanding its mechanisms and its role as a risk factor for most chronic conditions. Advancements marked by genome-wide association studies (GWASs) have sparked interest in gene cataloguing in the context of aging and age-related conditions. Here, we used GWAS to explore whether single nucleotide polymorphisms (SNPs) were associated with functional and anthropometric parameters in a cohort of old community-dwellers enrolled in the ilSIRENTE study. Analyses were carried out in men and women aged 80  years enrolled in the ilSIRENTE study (n = 286) and replicated in the inCHIANTI study (n = 1055). Genotyping was accomplished on Infinium Human610-QUAD version 1. In the ilSIRENTE population, genetic variants in ZNF295 and [[C2CD2]] (rs928874 and rs1788355) on chromosome 21q22.3, were significantly associated with the 4-meter gait speed (rs928874, p = 5.61 × 10 ; rs1788355, p = 5.73 × 10 ). This association was not replicated in the inCHIANTI population. Our findings suggest that specific SNPs may be associated with a key measure of physical performance in older adults. GWASs using larger samples are needed to confirm these preliminary results to enhance our comprehension of complex age-associated phenomena.
|mesh-terms=* Aged
* Aged, 80 and over
* Aging
* Anthropometry
* DNA-Binding Proteins
* Female
* Genetic Predisposition to Disease
* Genome-Wide Association Study
* Genotype
* Humans
* Male
* Membrane Proteins
* Physical Functional Performance
* Polymorphism, Single Nucleotide
* Transcription Factors
* Walking Speed

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5696534
}}