Редактирование: BTG4 (раздел)

==Publications==

{{medline-entry
|title=Age-related decrease of IF5/[[BTG4]] in oral and respiratory cavities in mice.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25660503
|abstract=An IF5 cDNA was isolated by expression cloning from a mouse oocyte cDNA library. It encoded a protein of 250 amino acids, and the region of it encoding amino acids 1-137 showed 86.8% alignment with the anti-proliferative domain of BTG/TOB family genes. This gene is also termed [[BTG4]] or PC3B. Transiently expressed IF5/[[BTG4]] induced alkaline phosphatase activity in human embryonic kidney (HEK293T) and 2T3 cells. IF5/[[BTG4]] mRNA was detected by reverse transcription polymerase chain reaction in pharynx, larynx, trachea, oviduct, ovary, caput epididymis, and testis, but not in lung, intestine, or liver. Immunohistochemistry showed the IF5/[[BTG4]] protein to be present in epithelial cells of the tongue, palate, pharynx, internal nose, and trachea. Both protein and mRNA levels of IF5/[[BTG4]] were reduced by aging when comparing 4-week-old mice with 48-week-old mice. Our findings suggest that IF5/[[BTG4]] may be an aging-related gene in epithelial cells. 
|mesh-terms=* Aging
* Alkaline Phosphatase
* Amino Acid Sequence
* Animals
* Base Sequence
* Cell Cycle Proteins
* Cell Differentiation
* Cell Proliferation
* Cloning, Molecular
* Down-Regulation
* Epithelial Cells
* Female
* HEK293 Cells
* Humans
* Mice
* Mice, Inbred C57BL
* Molecular Sequence Data
* Mouth
* Nasal Cavity
* RNA, Messenger
* Trachea
|keywords=* IF5/BTG4
* aging
* epithelium
* oral
* respiratory
|full-text-url=https://sci-hub.do/10.1080/09168451.2015.1008976
}}