Редактирование: BRINP1 (раздел)

==Publications==

{{medline-entry
|title=Absence of [[BRINP1]] in mice causes increase of hippocampal neurogenesis and behavioral alterations relevant to human psychiatric disorders.
|pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24528488
|abstract=We have previously identified BRINP (BMP/RA-inducible neural-specific protein-1, 2, 3) family genes that possess the ability to suppress cell cycle progression in neural stem cells. Of the three family members, [[BRINP1]] is the most highly expressed in various brain regions, including the hippocampus, in adult mice and its expression in dentate gyrus (DG) is markedly induced by neural activity. In the present study, we generated [[BRINP1]]-deficient (KO) mice to clarify the physiological functions of [[BRINP1]] in the nervous system. Neurogenesis in the subgranular zone of dentate gyrus was increased in [[BRINP1]]-KO mice creating a more immature neuronal population in granule cell layer. The number of parvalbumin expressing interneuron in hippocampal [[CA1]] subregion was also increased in [[BRINP1]]-KO mice. Furthermore, [[BRINP1]]-KO mice showed abnormal behaviors with increase in locomotor activity, reduced anxiety-like behavior, poor social interaction, and slight impairment of working memory, all of which resemble symptoms of human psychiatric disorders such as schizophrenia and attention-deficit/hyperactivity disorder (ADHD). Absence of [[BRINP1]] causes deregulation of neurogenesis and impairments of neuronal differentiation in adult hippocampal circuitry. Abnormal behaviors comparable to those of human psychiatric disorders such as hyperactivity and poor social behavior were observed in [[BRINP1]]-KO mice. These abnormal behaviors could be caused by alteration of hippocampal circuitry as a consequence of the lack of [[BRINP1]].
|mesh-terms=* Aging
* Animals
* Anxiety
* Behavior, Animal
* Biomarkers
* Cell Cycle Proteins
* Cell Differentiation
* Embryonic Stem Cells
* Exploratory Behavior
* Gene Targeting
* Hippocampus
* Humans
* Interneurons
* Maze Learning
* Memory, Short-Term
* Mental Disorders
* Mice
* Mice, Knockout
* Nerve Tissue Proteins
* Neurogenesis
* Parvalbumins
* Social Behavior

|full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3928644
}}