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Aging genes 30-59
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==STAT3== * {{medline-title |title=Dietary Restriction Suppresses Steatosis-Associated Hepatic Tumorigenesis in Hepatitis C Virus Core Gene Transgenic Mice. |date=09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33083279 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7548900 }} * {{medline-title |title=Skeletal glucocorticoid signalling determines leptin resistance and obesity in aging mice. |date=12.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/33045434 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7596342 }} * {{medline-title |title=AMPK alleviates oxidative stress‑induced premature senescence via inhibition of NF-κB/[[STAT3]] axis-mediated positive feedback loop. |date=10.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32882228 |full-text-url=https://sci-hub.do/10.1016/j.mad.2020.111347 }} * {{medline-title |title=Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through [[STAT3]] activation. |date=08.09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32848054 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7486730 }} * {{medline-title |title=Cell Death by Gallotannin Is Associated with Inhibition of the JAK/STAT Pathway in Human Colon Cancer Cells. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32714471 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7378856 }} * {{medline-title |title=The effect of interleukin 6 deficiency on myocardial signal transduction pathways activation induced by bacterial lipopolysaccharide in young and old mice. |date=09.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32693349 |full-text-url=https://sci-hub.do/10.1016/j.advms.2020.06.006 }} * {{medline-title |title=Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. |date=07.06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32517353 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7356916 }} * {{medline-title |title=Implication of JAK1/[[STAT3]]/SOCS3 Pathway in Aging of Cerebellum of Male Rat: Histological and Molecular study. |date=01.06.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32483368 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264275 }} * {{medline-title |title=Atorvastatin-induced senescence of hepatocellular carcinoma is mediated by downregulation of hTERT through the suppression of the IL-6/[[STAT3]] pathway. |date=2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32257389 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105491 }} * {{medline-title |title=Deciphering the Molecular Mechanism of Spontaneous Senescence in Primary Epithelial Ovarian Cancer Cells. |date=27.01.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/32012719 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7072138 }} * {{medline-title |title=Persistent Activation of [[STAT3]] Pathway in the Retina Induced Vision Impairment and Retinal Degenerative Changes in Ageing Mice. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31884637 |full-text-url=https://sci-hub.do/10.1007/978-3-030-27378-1_58 }} * {{medline-title |title=Interleukin-10 induces senescence of activated hepatic stellate cells via [[STAT3]]-p53 pathway to attenuate liver fibrosis. |date=02.2020 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31730896 |full-text-url=https://sci-hub.do/10.1016/j.cellsig.2019.109445 }} * {{medline-title |title=The proteasome activator REGγ counteracts immunoproteasome expression and autoimmunity. |date=09.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31171475 |full-text-url=https://sci-hub.do/10.1016/j.jaut.2019.05.010 }} * {{medline-title |title=Sexual dimorphism in rat thymic involution: a correlation with thymic oxidative status and inflammation. |date=08.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31119497 |full-text-url=https://sci-hub.do/10.1007/s10522-019-09816-3 }} * {{medline-title |title=Inflammaging: Age and Systemic, Cellular, and Nuclear Inflammatory Biology in Older Adults. |date=04.10.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31107949 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777092 }} * {{medline-title |title=A novel [[STAT3]] inhibitor, HJC0152, exerts potent antitumor activity in glioblastoma. |date=2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/31105997 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6511646 }} * {{medline-title |title=Congenital Hypothyroidism is Associated With Impairment of the Leptin Signaling Pathway in the Hypothalamus in Male Wistar Animals in Adult Life. |date=05.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30943548 |full-text-url=https://sci-hub.do/10.1055/a-0876-6007 }} * {{medline-title |title=mTORC1 underlies age-related muscle fiber damage and loss by inducing oxidative stress and catabolism. |date=06.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30924297 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6516169 }} * {{medline-title |title=[Tea polyphenols delays human glomerular mesangial cells senescence induced by high glucose via regulating [[STAT3]]/miR-126/telomere signaling pathway activation]. |date=12.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30717558 |full-text-url=https://sci-hub.do/10.19540/j.cnki.cjcmm.20181031.003 }} * {{medline-title |title=[[STAT3]] Regulates the Onset of Oxidant-induced Senescence in Lung Fibroblasts. |date=07.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30608861 |full-text-url=https://sci-hub.do/10.1165/rcmb.2018-0328OC }} * {{medline-title |title=Deciphering Molecular and Phenotypic Changes Associated with Early Autoimmune Disease in the Aire-Deficient Mouse Model of Sjögren's Syndrome. |date=17.11.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30453645 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274681 }} * {{medline-title |title=Senescent Breast Luminal Cells Promote Carcinogenesis through Interleukin-8-Dependent Activation of Stromal Fibroblasts. |date=15.01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30397077 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6321881 }} * {{medline-title |title=The role of [[STAT3]]/mTOR-regulated autophagy in angiotensin II-induced senescence of human glomerular mesangial cells. |date=01.2019 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30389500 |full-text-url=https://sci-hub.do/10.1016/j.cellsig.2018.10.021 }} * {{medline-title |title=A Novel [i]Dnmt3a1[/i] Transcript Inhibits Adipogenesis. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30333755 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6176318 }} * {{medline-title |title=Targeting a phospho-[[STAT3]]-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model. |date=11.09.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/30206377 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6134080 }} * {{medline-title |title=Decreased NAD Activates [[STAT3]] and Integrin Pathways to Drive Epithelial-Mesenchymal Transition. |date=10.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29980616 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6166677 }} * {{medline-title |title=Integrative Analysis of Hippocampus Gene Expression Profiles Identifies Network Alterations in Aging and Alzheimer's Disease. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29875655 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5974201 }} * {{medline-title |title=Overexpression of Klotho Inhibits HELF Fibroblasts SASP-related Protumoral Effects on Non-small Cell Lung Cancer Cells. |date=2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29675106 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5907673 }} * {{medline-title |title=Fibroblast senescence in the pathology of idiopathic pulmonary fibrosis. |date=01.08.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29696986 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6139657 }} * {{medline-title |title=Age-Associated Differences in Infection of Human Skin in the SCID Mouse Model of Varicella-Zoster Virus Pathogenesis. |date=01.06.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29563288 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5952162 }} * {{medline-title |title=[[MMP2]]-[[A2M]] interaction increases ECM accumulation in aged rat kidney and its modulation by calorie restriction. |date=19.01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29464020 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5814160 }} * {{medline-title |title=Deficiency in Protein Tyrosine Phosphatase PTP1B Shortens Lifespan and Leads to Development of Acute Leukemia. |date=01.01.2018 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29122767 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5756472 }} * {{medline-title |title=Chronic disruptions of circadian sleep regulation induce specific proinflammatory responses in the rat colon. |date=2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/29039977 |full-text-url=https://sci-hub.do/10.1080/07420528.2017.1361436 }} * {{medline-title |title=Genome-wide association study and annotating candidate gene networks affecting age at first calving in Nellore cattle. |date=12.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28994157 |full-text-url=https://sci-hub.do/10.1111/jbg.12299 }} * {{medline-title |title=The pathological roles of [[NDRG2]] in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells. |date=08.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28670853 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6492714 }} * {{medline-title |title=Maintenance of membrane organization in the aging mouse brain as the determining factor for preventing receptor dysfunction and for improving response to anti-Alzheimer treatments. |date=06.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28347928 |full-text-url=https://sci-hub.do/10.1016/j.neurobiolaging.2017.02.015 }} * {{medline-title |title=JAK-STAT signaling mediates the senescence of bone marrow-mesenchymal stem cells from systemic lupus erythematosus patients. |date=01.03.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28177455 |full-text-url=https://sci-hub.do/10.1093/abbs/gmw134 }} * {{medline-title |title=Hypothalamic S1P/[[S1PR1]] axis controls energy homeostasis in Middle-Aged Rodents: the reversal effects of physical exercise. |date=26.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28039439 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5310661 }} * {{medline-title |title=Intracerebroventricular tempol administration in older rats reduces oxidative stress in the hypothalamus but does not change [[STAT3]] signalling or [[SIRT1]]/AMPK pathway. |date=01.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/28006433 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522741 }} * {{medline-title |title=[[STAT3]]-mediated [[SMAD3]] activation underlies Oncostatin M-induced Senescence. |date=16.02.2017 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27892764 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5324753 }} * {{medline-title |title=Impaired Epidermal to Dendritic T Cell Signaling Slows Wound Repair in Aged Skin. |date=17.11.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27863246 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5364946 }} * {{medline-title |title=Aging amplifies multiple phenotypic defects in mice with zinc transporter Zip14 (Slc39a14) deletion. |date=01.12.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27647172 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5101137 }} * {{medline-title |title=The role of STAT transcription factors in apoptosis regulation of hypothalamic neurons in aging in HER-2/neu transgenic mice and wild-type FVB/N mice. |date=05.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27417725 |full-text-url=https://sci-hub.do/10.1134/S1607672916030169 }} * {{medline-title |title=Exogenous H2S contributes to recovery of ischemic post-conditioning-induced cardioprotection by decrease of ROS level via down-regulation of NF-κB and [[JAK2]]-[[STAT3]] pathways in the aging cardiomyocytes. |date=2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27096074 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4836181 }} * {{medline-title |title=Enhanced Transcriptional Activity and Mitochondrial Localization of [[STAT3]] Co-induce Axon Regrowth in the Adult Central Nervous System. |date=12.04.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/27050520 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4833545 }} * {{medline-title |title=The Inflammatory Transcription Factors NFκB, [[STAT1]] and [[STAT3]] Drive Age-Associated Transcriptional Changes in the Human Kidney. |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26678048 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4682820 }} * {{medline-title |title=[Epidermal aging and anti-aging strategies]. |date=02.2016 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26636143 |full-text-url=https://sci-hub.do/10.1007/s00105-015-3734-6 }} * {{medline-title |title=Seipin knockout in mice impairs stem cell proliferation and progenitor cell differentiation in the adult hippocampal dentate gyrus via reduced levels of PPARγ. |date=12.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26398946 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4728316 }} * {{medline-title |title=[[IL10]]-driven [[STAT3]] signalling in senescent macrophages promotes pathological eye angiogenesis. |date=11.08.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26260587 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918330 }} * {{medline-title |title=Down-regulation of mir-542-3p promotes neointimal formation in the aging rat. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26026397 |full-text-url=https://sci-hub.do/10.1016/j.vph.2015.05.010 }} * {{medline-title |title=CD4⁺[[CD28]]null T lymphocytes resemble CD8⁺[[CD28]]null T lymphocytes in their responses to IL-15 and IL-21 in HIV-infected patients. |date=09.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/26034206 |full-text-url=https://sci-hub.do/10.1189/jlb.1A0514-276RR }} * {{medline-title |title=Constitutive [[STAT3]] activation in epidermal keratinocytes enhances cell clonogenicity and favours spontaneous immortalization by opposing differentiation and senescence checkpoints. |date=01.2015 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25382846 |full-text-url=https://sci-hub.do/10.1111/exd.12585 }} * {{medline-title |title=[[STAT3]] signaling controls satellite cell expansion and skeletal muscle repair. |date=10.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/25194572 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332844 }} * {{medline-title |title=Aging impairs transcriptional regulation of vascular endothelial growth factor in human microvascular endothelial cells: implications for angiogenesis and cell survival. |date=04.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24781730 }} * {{medline-title |title=Gene expression profiling of Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly reveals alterations of characteristic oncogenetic pathways. |date=05.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24581222 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317839 }} * {{medline-title |title=[[STAT3]] and metabolism: how many ways to use a single molecule? |date=01.11.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24500994 |full-text-url=https://sci-hub.do/10.1002/ijc.28767 }} * {{medline-title |title=Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. |date=21.02.2014 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24403063 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3931022 }} * {{medline-title |title=IL-6-[[STAT3]] signaling and premature senescence. |date=01.10.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24416650 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876432 }} * {{medline-title |title=From cirrhosis to hepatocellular carcinoma: new molecular insights on inflammation and cellular senescence. |date=08.2013 |pubmed-url=https://pubmed.ncbi.nlm.nih.gov/24400224 |full-text-url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3881319 }}
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